PDB entry 4eop
View 4eop on RCSB PDB site
Description: Thr 160 phosphorylated CDK2 Q131E - human cyclin A3 complex with the inhibitor RO3306
Class: transferase/transferase inhibitor
Keywords: protein kinase, cell cycle, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on
2012-04-14, released
2013-02-06
The last revision prior to the SCOPe 2.02 freeze date was dated
2013-02-06, with a file datestamp of
2013-02-01.
Experiment type: XRAY
Resolution: 1.99 Å
R-factor: 0.217
AEROSPACI score: 0.43
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: cyclin-dependent kinase 2
Species: Homo sapiens [TaxId:9606]
Gene: CDK2, CDKN2
Database cross-references and differences (RAF-indexed):
- Uniprot P24941 (3-299)
- expression tag (0-2)
- engineered mutation (133)
Domains in SCOPe 2.02: d4eopa_ - Chain 'B':
Compound: Cyclin-A2
Species: Homo sapiens [TaxId:9606]
Gene: CCNA2, CCN1, CCNA
Database cross-references and differences (RAF-indexed):
- Chain 'C':
Compound: cyclin-dependent kinase 2
Species: Homo sapiens [TaxId:9606]
Gene: CDK2, CDKN2
Database cross-references and differences (RAF-indexed):
- Uniprot P24941 (3-End)
- expression tag (2)
- engineered mutation (133)
Domains in SCOPe 2.02: d4eopc_ - Chain 'D':
Compound: Cyclin-A2
Species: Homo sapiens [TaxId:9606]
Gene: CCNA2, CCN1, CCNA
Database cross-references and differences (RAF-indexed):
- Heterogens: 1RO, SGM, MG, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4eopA (A:)
pgsmenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllke
lnhpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglaf
chshrvlhrdlkpenllintegaikladfglarafgvpvrtythevvtlwyrapeillgc
kyystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdyk
psfpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlr
Sequence, based on observed residues (ATOM records): (download)
>4eopA (A:)
pgsmenfqkvekigegtygvvykarnkltgevvalkkirldtegvpstaireisllkeln
hpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafch
shrvlhrdlkpenllintegaikladfglarafgvpvrtythevvtlwyrapeillgcky
ystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykps
fpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlr
- Chain 'B':
No sequence available.
- Chain 'C':
Sequence, based on SEQRES records: (download)
>4eopC (C:)
pgsmenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllke
lnhpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglaf
chshrvlhrdlkpenllintegaikladfglarafgvpvrtythevvtlwyrapeillgc
kyystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdyk
psfpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlr
Sequence, based on observed residues (ATOM records): (download)
>4eopC (C:)
smenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkeln
hpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafch
shrvlhrdlkpenllintegaikladfglarafgvpvrtythevvtlwyrapeillgcky
ystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykps
fpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphl
- Chain 'D':
No sequence available.