PDB entry 4eom

View 4eom on RCSB PDB site
Description: Thr 160 phosphorylated CDK2 H84S, Q85M, Q131E - human cyclin A3 complex with ATP
Class: transferase, cell cycle
Keywords: protein kinase, cell cycle, complex, PHOSPHORYLATION, TRANSFERASE
Deposited on 2012-04-14, released 2013-02-06
The last revision prior to the SCOPe 2.03 freeze date was dated 2013-02-06, with a file datestamp of 2013-02-01.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.21
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cyclin-dependent kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CDK2, CDKN2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P24941 (4-300)
      • expression tag (2-3)
      • engineered mutation (87-88)
      • engineered mutation (134)
    Domains in SCOPe 2.03: d4eoma_
  • Chain 'B':
    Compound: Cyclin-A2
    Species: Homo sapiens [TaxId:9606]
    Gene: CCNA2, CCN1, CCNA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4eomb1, d4eomb2
  • Chain 'C':
    Compound: cyclin-dependent kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CDK2, CDKN2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P24941 (4-End)
      • expression tag (0-3)
      • engineered mutation (87-88)
      • engineered mutation (134)
    Domains in SCOPe 2.03: d4eomc_
  • Chain 'D':
    Compound: Cyclin-A2
    Species: Homo sapiens [TaxId:9606]
    Gene: CCNA2, CCN1, CCNA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4eomd1, d4eomd2
  • Heterogens: ATP, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4eomA (A:)
plgsmenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllk
elnhpnivklldvihtenklylvfeflsmdlkkfmdasaltgiplpliksylfqllqgla
fchshrvlhrdlkpenllintegaikladfglarafgvpvrtythevvtlwyrapeillg
ckyystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdy
kpsfpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphl
r

    Sequence, based on observed residues (ATOM records): (download) 
    >4eomA (A:)
gsmenfqkvekigegtygvvykarnkltgevvalkkirletegvpstaireisllkelnh
pnivklldvihtenklylvfeflsmdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpenllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4eomB (B:)
vpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhl
avnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvlrm
ehlvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylkylpsv
iagaafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqqsirekyk
nskyhgvsllnppetlnl

    Sequence, based on observed residues (ATOM records): (download) 
    >4eomB (B:)
pdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhla
vnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvlrme
hlvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylkylpsvi
agaafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqqsirekykn
skyhgvsllnppetlnl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4eomC (C:)
plgsmenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllk
elnhpnivklldvihtenklylvfeflsmdlkkfmdasaltgiplpliksylfqllqgla
fchshrvlhrdlkpenllintegaikladfglarafgvpvrtythevvtlwyrapeillg
ckyystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdy
kpsfpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphl
r

    Sequence, based on observed residues (ATOM records): (download) 
    >4eomC (C:)
plgsmenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllk
elnhpnivklldvihtenklylvfeflsmdlkkfmdasaltgiplpliksylfqllqgla
fchshrvlhrdlkpenllintegaikladfglarafgvpvrtythevvtlwyrapeillg
ckyystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtqdfskvvppldedgr
sllsqmlhydpnkrisakaalahpffqdvtkpvphl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4eomD (D:)
vpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhl
avnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvlrm
ehlvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylkylpsv
iagaafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqqsirekyk
nskyhgvsllnppetlnl

    Sequence, based on observed residues (ATOM records): (download) 
    >4eomD (D:)
pdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhla
vnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvlrme
hlvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylkylpsvi
agaafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqqsirekykn
skyhgvsllnppet