PDB entry 4eg6
View 4eg6 on RCSB PDB site
Description: Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor Chem 1325
Class: ligase/ligase inhibitor
Keywords: aminoacyl-tRNA synthetase, aaRS, MetRS, parasite, ligase, protein-inhibitor complex, Rossmann-fold, translation, nucleotide binding,, Rossmann Fold, tRNA binding ATP binding, LIGASE-LIGASE INHIBITOR complex
Deposited on
2012-03-30, released
2012-09-12
The last revision prior to the SCOPe 2.03 freeze date was dated
2012-10-31, with a file datestamp of
2012-10-26.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.192
AEROSPACI score: 0.28
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Methionyl-tRNA synthetase, putative
Species: Trypanosoma brucei brucei [TaxId:999953]
Gene: Tb10.70.6470
Database cross-references and differences (RAF-indexed):
- Uniprot Q38C91
- conflict (77)
- engineered mutation (220-222)
- conflict (267)
- conflict (271)
- Chain 'B':
Compound: Methionyl-tRNA synthetase, putative
Species: Trypanosoma brucei brucei [TaxId:999953]
Gene: Tb10.70.6470
Database cross-references and differences (RAF-indexed):
- Uniprot Q38C91 (3-End)
- expression tag (0-2)
- conflict (4)
- conflict (77)
- engineered mutation (220-222)
- conflict (267)
- conflict (271)
Domains in SCOPe 2.03: d4eg6b1, d4eg6b2 - Heterogens: GOL, DMS, MET, SO4, 0P5, HOH
PDB Chain Sequences:
- Chain 'A':
No sequence available.
- Chain 'B':
Sequence, based on SEQRES records: (download)
>4eg6B (B:)
gpgsmkvekvffvtspiyyvnaaphighvystlitdvigryhrvkgervfaltgtdehgq
kvaeaakqkqvspydfttavagefkkcfeqmdysidyfirttneqhkavvkelwtkleqk
gdiylgryegwysisdesfltpqnitdgvdkdgnpckvslesghvvtwvseenymfrlsa
frerllewyhanpgcivpefrrreviravekglpdlsvsraratlhnwaipvpgnpdhcv
yvwldaltnyltgsrlrvdesgkevslvddfnelerfpadvhvigkdilkfhaiywpafl
lsaglplpkkivahgwwtkdrkkiskslgnvfdpvekaeefgydalkyfllresgfsddg
dysdknmiarlngeladtlgnlvmrctsakinvngewpspaayteedesliqlikdlpgt
adhyylipdiqkaiiavfdvlrainayvtdmapwklvktdperlrtvlyitlegvrvttl
llspilprksvvifdmlgvpevhrkgienfefgavppgtrlgpavegevlfskrstentk
st
Sequence, based on observed residues (ATOM records): (download)
>4eg6B (B:)
gpgsmkvekvffvtspiyyvnaaphighvystlitdvigryhrvkgervfaltgtdehgq
kvaeaakqkqvspydfttavagefkkcfeqmdysidyfirttneqhkavvkelwtkleqk
gdiylgryegwysisdesfltpqnitwvseenymfrlsafrerllewyhanpgcivpefr
rreviravekglpdlsvsraratlhnwaipvpgnpdhcvyvwldaltnyltgsrlrvdes
gkevslvddfnelerfpadvhvigkdilkfhaiywpafllsaglplpkkivahgwwtkdr
kkiskslgnvfdpvekaeefgydalkyfllresgfsddgdysdknmiarlngeladtlgn
lvmrctsakinvngewpspaayteedesliqlikdlpgtadhyylipdiqkaiiavfdvl
rainayvtdmapwklvktdperlrtvlyitlegvrvttlllspilprksvvifdmlgvpe
vhrkgienfefgavppgtrlgpavegevlfskrst