PDB entry 4edx
View 4edx on RCSB PDB site
Description: Nerve Growth Factor in Complex with Fab from mouse mAb 911
Class: immune system
Keywords: cystine knot, immunoglobulin, growth/survival factor, immune system
Deposited on
2012-03-27, released
2014-04-02
The last revision prior to the SCOPe 2.06 freeze date was dated
2014-08-13, with a file datestamp of
2014-08-08.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.209
AEROSPACI score: 0.24
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: light chain of FAB of murine anti-NGF
Species: Mus musculus [TaxId:10090]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d4edxa1, d4edxa2 - Chain 'B':
Compound: heavy chain of Fab of murine anti-NGF
Species: Mus musculus [TaxId:10090]
Database cross-references and differences (RAF-indexed):
- Chain 'H':
Compound: heavy chain of Fab of murine anti-NGF
Species: Mus musculus [TaxId:10090]
Database cross-references and differences (RAF-indexed):
- Chain 'L':
Compound: light chain of FAB of murine anti-NGF
Species: Mus musculus [TaxId:10090]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d4edxl1, d4edxl2 - Chain 'V':
Compound: Beta-nerve growth factor
Species: Homo sapiens [TaxId:9606]
Gene: Ngf, Ngfb
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d4edxv_ - Chain 'W':
Compound: Beta-nerve growth factor
Species: Homo sapiens [TaxId:9606]
Gene: Ngf, Ngfb
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d4edxw_ - Heterogens: HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>4edxA (A:)
diqmtqttsslsaslgdrvtiscrasqdisnhlnwyqqkpdgtvklliyyisrfhsgvps
rfsgsgsgtdysltisnleqediatyfcqqsktlpytfgggtkleikradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrnec
- Chain 'B':
No sequence available.
- Chain 'H':
No sequence available.
- Chain 'L':
Sequence; same for both SEQRES and ATOM records: (download)
>4edxL (L:)
diqmtqttsslsaslgdrvtiscrasqdisnhlnwyqqkpdgtvklliyyisrfhsgvps
rfsgsgsgtdysltisnleqediatyfcqqsktlpytfgggtkleikradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrnec
- Chain 'V':
Sequence, based on SEQRES records: (download)
>4edxV (V:)
ssshpifhrgefsvcdsvsvwvgdkttatdikgkevmvlgevninnsvfkqyffetkcrd
pnpvdsgcrgidskhwnsycttthtfvkaltmdgkqaawrfiridtacvcvlsrkavrra
Sequence, based on observed residues (ATOM records): (download)
>4edxV (V:)
gefsvcdsvsvwvgdkttatdikgkevmvlgevninnsvfkqyffetkcrdgcrgidskh
wnsycttthtfvkaltmdgkqaawrfiridtacvcvlsrka
- Chain 'W':
Sequence, based on SEQRES records: (download)
>4edxW (W:)
ssshpifhrgefsvcdsvsvwvgdkttatdikgkevmvlgevninnsvfkqyffetkcrd
pnpvdsgcrgidskhwnsycttthtfvkaltmdgkqaawrfiridtacvcvlsrkavrra
Sequence, based on observed residues (ATOM records): (download)
>4edxW (W:)
gefsvcdsvsvwvgdkttatdikgkevmvlgevninnsvfkqyffetkcrdsgcrgidsk
hwnsycttthtfvkaltmdgkqaawrfiridtacvcvlsrka