PDB entry 4ebw

View 4ebw on RCSB PDB site
Description: Structure of Focal Adhesion Kinase catalytic domain in complex with novel allosteric inhibitor
Class: transferase/transferase inhibitor
Keywords: Kinase Domain, Allosteric inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2012-03-25, released 2012-07-25
The last revision prior to the SCOPe 2.03 freeze date was dated 2013-03-27, with a file datestamp of 2013-03-22.
Experiment type: XRAY
Resolution: 2.65 Å
R-factor: 0.186
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Focal adhesion kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PTK2, FAK, FAK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4ebwa_
  • Heterogens: 0PF, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4ebwA (A:)
msyyhhhhhhdydipttenlyfqgamgsstrdyeiqrerielgrcigegqfgdvhqgiym
spenpalavaiktcknctsdsvrekflqealtmrqfdhphivkligvitenpvwiimelc
tlgelrsflqvrkysldlaslilyayqlstalayleskrfvhrdiaarnvlvssndcvkl
gdfglsrymedstyykaskgklpikwmapesinfrrftsasdvwmfgvcmweilmhgvkp
fqgvknndvigriengerlpmppncpptlyslmtkcwaydpsrrprftelkaqlstilee
ekaq

    Sequence, based on observed residues (ATOM records): (download) 
    >4ebwA (A:)
strdyeiqrerielgrcigegqfgdvhqgiymsnpalavaiktcknctsdsvrekflqea
ltmrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilyayqlst
alayleskrfvhrdiaarnvlvssndcvklgdfglklpikwmapesinfrrftsasdvwm
fgvcmweilmhgvkpfqgvknndvigriengerlpmppncpptlyslmtkcwaydpsrrp
rftelkaqlstileeekaq