PDB entry 4e6q

View 4e6q on RCSB PDB site
Description: JAK2 kinase (JH1 domain) triple mutant in complex with compound 12
Class: transferase/transferase inhibitor
Keywords: JAK2, kinase domain, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2012-03-15, released 2012-05-30
The last revision prior to the SCOPe 2.06 freeze date was dated 2012-07-11, with a file datestamp of 2012-07-06.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: 0.189
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60674 (0-297)
      • engineered mutation (18)
      • engineered mutation (96)
      • engineered mutation (104)
    Domains in SCOPe 2.06: d4e6qa_
  • Chain 'B':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60674 (0-297)
      • engineered mutation (18)
      • engineered mutation (96)
      • engineered mutation (104)
    Domains in SCOPe 2.06: d4e6qb_
  • Heterogens: 0NV, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4e6qA (A:)
afedrdptqfeerhlkflrqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrd
fereieilkslqhdnivkykgvcysagrrnlklimeflpygslreylqkhkeridhikll
qytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepg
espifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmi
vfhliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4e6qB (B:)
afedrdptqfeerhlkflrqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrd
fereieilkslqhdnivkykgvcysagrrnlklimeflpygslreylqkhkeridhikll
qytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepg
espifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmi
vfhliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag