PDB entry 4e4v

View 4e4v on RCSB PDB site
Description: The crystal structure of the dimeric human importin alpha 1 at 2.5 angstrom resolution.
Class: transport protein
Keywords: armadillo repeat, karyopherin, importin, nuclear import, host-virus interaction, nucleus, phosphoprotein, protein transport, transport, transport protein
Deposited on 2012-03-13, released 2013-05-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 2.53 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Importin subunit alpha-2
    Species: Homo sapiens [TaxId:9606]
    Gene: IP0A1, KPNA2, RCH1, SRP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52292 (25-End)
      • expression tag (20-24)
      • engineered mutation (441)
    Domains in SCOPe 2.08: d4e4va1, d4e4va2
  • Chain 'B':
    Compound: Importin subunit alpha-2
    Species: Homo sapiens [TaxId:9606]
    Gene: IP0A1, KPNA2, RCH1, SRP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52292 (25-End)
      • expression tag (20-24)
      • engineered mutation (441)
    Domains in SCOPe 2.08: d4e4vb1, d4e4vb2
  • Heterogens: GOL, DTT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4e4vA (A:)
mgsshhhhhssgenlyfqghmldalnqgtvnwsvddivkginssnvenqlqatqaarkll
srekqppidniiraglipkfvsflgrtdcspiqfesawaltniasgtseqtkavvdggai
pafisllasphahiseqavwalgniagdgsvfrdlvikygavdpllallavpdmsslacg
ylrnltwtlsnlcrnknpappidaveqilptlvrllhhddpevladtcwaisyltdgpne
rigmvvktgvvpqlvkllgaselpivtpalraignivtgtdeqtqvvidagalavfpsll
tnpktniqkeatwtmsnitagrqdqiqqvvnhglvpflvsvlskadfktqkeavwavtny
tsggtveqivylvhcgiieplmnlltakdtkiilvildaisnifqaaeklgeteklsimi
eecggldkiealqnhenesvyraslsliekyfsveeeedqnvvpettsegytfqvqdgap
gtfnf

    Sequence, based on observed residues (ATOM records): (download) 
    >4e4vA (A:)
mldalnqgtvnwsvddivkginssnvenqlqatqaarkllsrekqppidniiraglipkf
vsflgrtdcspiqfesawaltniasgtseqtkavvdggaipafisllasphahiseqavw
algniagdgsvfrdlvikygavdpllallavpdmsslacgylrnltwtlsnlcrnknpap
pidaveqilptlvrllhhddpevladtcwaisyltdgpnerigmvvktgvvpqlvkllga
selpivtpalraignivtgtdeqtqvvidagalavfpslltnpktniqkeatwtmsnita
grqdqiqqvvnhglvpflvsvlskadfktqkeavwavtnytsggtveqivylvhcgiiep
lmnlltakdtkiilvildaisnifqaaeklgeteklsimieecggldkiealqnhenesv
yraslsliekyfs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4e4vB (B:)
mgsshhhhhssgenlyfqghmldalnqgtvnwsvddivkginssnvenqlqatqaarkll
srekqppidniiraglipkfvsflgrtdcspiqfesawaltniasgtseqtkavvdggai
pafisllasphahiseqavwalgniagdgsvfrdlvikygavdpllallavpdmsslacg
ylrnltwtlsnlcrnknpappidaveqilptlvrllhhddpevladtcwaisyltdgpne
rigmvvktgvvpqlvkllgaselpivtpalraignivtgtdeqtqvvidagalavfpsll
tnpktniqkeatwtmsnitagrqdqiqqvvnhglvpflvsvlskadfktqkeavwavtny
tsggtveqivylvhcgiieplmnlltakdtkiilvildaisnifqaaeklgeteklsimi
eecggldkiealqnhenesvyraslsliekyfsveeeedqnvvpettsegytfqvqdgap
gtfnf

    Sequence, based on observed residues (ATOM records): (download) 
    >4e4vB (B:)
mldalnqgtvnwsvddivkginssnvenqlqatqaarkllsrekqppidniiraglipkf
vsflgrtdcspiqfesawaltniasgtseqtkavvdggaipafisllasphahiseqavw
algniagdgsvfrdlvikygavdpllallavpdmsslacgylrnltwtlsnlcrnknpap
pidaveqilptlvrllhhddpevladtcwaisyltdgpnerigmvvktgvvpqlvkllga
selpivtpalraignivtgtdeqtqvvidagalavfpslltnpktniqkeatwtmsnita
grqdqiqqvvnhglvpflvsvlskadfktqkeavwavtnytsggtveqivylvhcgiiep
lmnlltakdtkiilvildaisnifqaaeklgeteklsimieecggldkiealqnhenesv
yraslsliekyfs