PDB entry 4e4m

View 4e4m on RCSB PDB site
Description: JAK2 kinase (JH1 domain) in complex with compound 30
Class: transferase/transferase inhibitor
Keywords: o-phosphotyrosine, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2012-03-13, released 2012-05-30
The last revision prior to the SCOPe 2.06 freeze date was dated 2012-07-11, with a file datestamp of 2012-07-06.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: 0.193
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4e4ma_
  • Chain 'B':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4e4mb_
  • Chain 'D':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4e4md_
  • Chain 'E':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4e4me_
  • Heterogens: 0NH, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4e4mA (A:)
gssgafedrdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhstee
hlrdfereieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridh
ikllqytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykv
kepgespifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkq
gqmivfhliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnm
ag

    Sequence, based on observed residues (ATOM records): (download) 
    >4e4mA (A:)
afedrdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrd
fereieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikll
qytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepg
espifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmi
vfhliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4e4mB (B:)
gssgafedrdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhstee
hlrdfereieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridh
ikllqytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykv
kepgespifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkq
gqmivfhliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnm
ag

    Sequence, based on observed residues (ATOM records): (download) 
    >4e4mB (B:)
afedrdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrd
fereieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikll
qytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepg
espifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmi
vfhliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4e4mD (D:)
gssgafedrdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhstee
hlrdfereieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridh
ikllqytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykv
kepgespifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkq
gqmivfhliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnm
ag

    Sequence, based on observed residues (ATOM records): (download) 
    >4e4mD (D:)
afedrdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrd
fereieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikll
qytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepg
espifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmi
vfhliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4e4mE (E:)
gssgafedrdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhstee
hlrdfereieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridh
ikllqytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykv
kepgespifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkq
gqmivfhliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnm
ag

    Sequence, based on observed residues (ATOM records): (download) 
    >4e4mE (E:)
afedrdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrd
fereieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikll
qytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepg
espifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmi
vfhliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag