PDB entry 4e1o

View 4e1o on RCSB PDB site
Description: Human histidine decarboxylase complex with Histidine methyl ester (HME)
Class: lyase
Keywords: Histidine decarboxylase, LYASE
Deposited on 2012-03-06, released 2012-07-18
The last revision prior to the SCOPe 2.05 freeze date was dated 2013-07-17, with a file datestamp of 2013-07-12.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.163
AEROSPACI score: 0.54 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: histidine decarboxylase
    Species: Homo sapiens [TaxId:9606]
    Gene: HDC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P19113 (5-480)
      • expression tag (4)
      • engineered mutation (183)
      • engineered mutation (421)
    Domains in SCOPe 2.05: d4e1oa_
  • Chain 'B':
    Compound: histidine decarboxylase
    Species: Homo sapiens [TaxId:9606]
    Gene: HDC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P19113 (5-480)
      • expression tag (4)
      • engineered mutation (183)
      • engineered mutation (421)
    Domains in SCOPe 2.05: d4e1ob_
  • Chain 'C':
    Compound: histidine decarboxylase
    Species: Homo sapiens [TaxId:9606]
    Gene: HDC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P19113 (5-480)
      • expression tag (0-4)
      • engineered mutation (183)
      • engineered mutation (421)
    Domains in SCOPe 2.05: d4e1oc_
  • Chain 'D':
    Compound: histidine decarboxylase
    Species: Homo sapiens [TaxId:9606]
    Gene: HDC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P19113 (5-480)
      • expression tag (3-4)
      • engineered mutation (183)
      • engineered mutation (421)
    Domains in SCOPe 2.05: d4e1od_
  • Chain 'E':
    Compound: histidine decarboxylase
    Species: Homo sapiens [TaxId:9606]
    Gene: HDC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P19113 (5-480)
      • expression tag (3-4)
      • engineered mutation (183)
      • engineered mutation (421)
    Domains in SCOPe 2.05: d4e1oe_
  • Chain 'F':
    Compound: histidine decarboxylase
    Species: Homo sapiens [TaxId:9606]
    Gene: HDC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P19113 (5-480)
      • expression tag (3-4)
      • engineered mutation (183)
      • engineered mutation (421)
    Domains in SCOPe 2.05: d4e1of_
  • Heterogens: PLP, PVH, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4e1oA (A:)
    gplgsmepeeyrergremvdyicqylstvrerrvtpdvqpgylraqlpesapedpdswds
    ifgdieriimpgvvhwqsphmhayypaltswpsllgdmladainclgftwasspactele
    mnvmdwlakmlglpehflhhhpssqgggvlqstvsestliallaarknkilemktsepda
    desslnarlvayasdqahssvekaglislvkmkflpvddnfslrgealqkaieedkqrgl
    vpvfvcatlgttgvcafdclselgpicareglwlhidaayagtaflcpefrgflkgieya
    dsftfnpskwmmvhfdctgfwvkdkyklqqtfsvnpiylrhansgvatdfmhwqiplsrr
    frsvklwfvirsfgvknlqahvrhgtemakyfeslvrndpsfeipakrhlglvvfrlkgp
    nsltenvlkeiakagrlflipatiqdkliirftvtsqfttrddilrdwnlirdaatlils
    q
    

    Sequence, based on observed residues (ATOM records): (download)
    >4e1oA (A:)
    smepeeyrergremvdyicqylstvrerrvtpdvqpgylraqlpesapedpdswdsifgd
    ieriimpgvvhwqsphmhayypaltswpsllgdmladainclgftwasspactelemnvm
    dwlakmlglpehflhhhpssqgggvlqstvsestliallaarknkilemktsepdadess
    lnarlvayasdqahssvekaglislvkmkflpvddnfslrgealqkaieedkqrglvpvf
    vcatlgttgvcafdclselgpicareglwlhidaayagtaflcpefrgflkgieyadsft
    fnpskwmmvhfdctgfwvkdkyklqqtfsvnpiylrhansgvatdfmhwqiplsrrfrsv
    klwfvirsfgvknlqahvrhgtemakyfeslvrndpsfeipakrhlglvvfrlkgpnslt
    envlkeiakagrlflipatiqdkliirftvtsqfttrddilrdwnlirdaatlilsq
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4e1oB (B:)
    gplgsmepeeyrergremvdyicqylstvrerrvtpdvqpgylraqlpesapedpdswds
    ifgdieriimpgvvhwqsphmhayypaltswpsllgdmladainclgftwasspactele
    mnvmdwlakmlglpehflhhhpssqgggvlqstvsestliallaarknkilemktsepda
    desslnarlvayasdqahssvekaglislvkmkflpvddnfslrgealqkaieedkqrgl
    vpvfvcatlgttgvcafdclselgpicareglwlhidaayagtaflcpefrgflkgieya
    dsftfnpskwmmvhfdctgfwvkdkyklqqtfsvnpiylrhansgvatdfmhwqiplsrr
    frsvklwfvirsfgvknlqahvrhgtemakyfeslvrndpsfeipakrhlglvvfrlkgp
    nsltenvlkeiakagrlflipatiqdkliirftvtsqfttrddilrdwnlirdaatlils
    q
    

    Sequence, based on observed residues (ATOM records): (download)
    >4e1oB (B:)
    smepeeyrergremvdyicqylstvrerrvtpdvqpgylraqlpesapedpdswdsifgd
    ieriimpgvvhwqsphmhayypaltswpsllgdmladainclgftwasspactelemnvm
    dwlakmlglpehflhhhpssqgggvlqstvsestliallaarknkilemktsepdadess
    lnarlvayasdqahssvekaglislvkmkflpvddnfslrgealqkaieedkqrglvpvf
    vcatlgttgvcafdclselgpicareglwlhidaayagtaflcpefrgflkgieyadsft
    fnpskwmmvhfdctgfwvkdkyklqqtfsvnpiylrhansgvatdfmhwqiplsrrfrsv
    klwfvirsfgvknlqahvrhgtemakyfeslvrndpsfeipakrhlglvvfrlkgpnslt
    envlkeiakagrlflipatiqdkliirftvtsqfttrddilrdwnlirdaatlilsq
    

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4e1oC (C:)
    gplgsmepeeyrergremvdyicqylstvrerrvtpdvqpgylraqlpesapedpdswds
    ifgdieriimpgvvhwqsphmhayypaltswpsllgdmladainclgftwasspactele
    mnvmdwlakmlglpehflhhhpssqgggvlqstvsestliallaarknkilemktsepda
    desslnarlvayasdqahssvekaglislvkmkflpvddnfslrgealqkaieedkqrgl
    vpvfvcatlgttgvcafdclselgpicareglwlhidaayagtaflcpefrgflkgieya
    dsftfnpskwmmvhfdctgfwvkdkyklqqtfsvnpiylrhansgvatdfmhwqiplsrr
    frsvklwfvirsfgvknlqahvrhgtemakyfeslvrndpsfeipakrhlglvvfrlkgp
    nsltenvlkeiakagrlflipatiqdkliirftvtsqfttrddilrdwnlirdaatlils
    q
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >4e1oD (D:)
    gplgsmepeeyrergremvdyicqylstvrerrvtpdvqpgylraqlpesapedpdswds
    ifgdieriimpgvvhwqsphmhayypaltswpsllgdmladainclgftwasspactele
    mnvmdwlakmlglpehflhhhpssqgggvlqstvsestliallaarknkilemktsepda
    desslnarlvayasdqahssvekaglislvkmkflpvddnfslrgealqkaieedkqrgl
    vpvfvcatlgttgvcafdclselgpicareglwlhidaayagtaflcpefrgflkgieya
    dsftfnpskwmmvhfdctgfwvkdkyklqqtfsvnpiylrhansgvatdfmhwqiplsrr
    frsvklwfvirsfgvknlqahvrhgtemakyfeslvrndpsfeipakrhlglvvfrlkgp
    nsltenvlkeiakagrlflipatiqdkliirftvtsqfttrddilrdwnlirdaatlils
    q
    

    Sequence, based on observed residues (ATOM records): (download)
    >4e1oD (D:)
    gsmepeeyrergremvdyicqylstvrerrvtpdvqpgylraqlpesapedpdswdsifg
    dieriimpgvvhwqsphmhayypaltswpsllgdmladainclgftwasspactelemnv
    mdwlakmlglpehflhhhpssqgggvlqstvsestliallaarknkilemktsepdades
    slnarlvayasdqahssvekaglislvkmkflpvddnfslrgealqkaieedkqrglvpv
    fvcatlgttgvcafdclselgpicareglwlhidaayagtaflcpefrgflkgieyadsf
    tfnpskwmmvhfdctgfwvkdkyklqqtfsvnpiylrhansgvatdfmhwqiplsrrfrs
    vklwfvirsfgvknlqahvrhgtemakyfeslvrndpsfeipakrhlglvvfrlkgpnsl
    tenvlkeiakagrlflipatiqdkliirftvtsqfttrddilrdwnlirdaatlilsq
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >4e1oE (E:)
    gplgsmepeeyrergremvdyicqylstvrerrvtpdvqpgylraqlpesapedpdswds
    ifgdieriimpgvvhwqsphmhayypaltswpsllgdmladainclgftwasspactele
    mnvmdwlakmlglpehflhhhpssqgggvlqstvsestliallaarknkilemktsepda
    desslnarlvayasdqahssvekaglislvkmkflpvddnfslrgealqkaieedkqrgl
    vpvfvcatlgttgvcafdclselgpicareglwlhidaayagtaflcpefrgflkgieya
    dsftfnpskwmmvhfdctgfwvkdkyklqqtfsvnpiylrhansgvatdfmhwqiplsrr
    frsvklwfvirsfgvknlqahvrhgtemakyfeslvrndpsfeipakrhlglvvfrlkgp
    nsltenvlkeiakagrlflipatiqdkliirftvtsqfttrddilrdwnlirdaatlils
    q
    

    Sequence, based on observed residues (ATOM records): (download)
    >4e1oE (E:)
    gsmepeeyrergremvdyicqylstvrerrvtpdvqpgylraqlpesapedpdswdsifg
    dieriimpgvvhwqsphmhayypaltswpsllgdmladainclgftwasspactelemnv
    mdwlakmlglpehflhhhpssqgggvlqstvsestliallaarknkilemktsepdades
    slnarlvayasdqahssvekaglislvkmkflpvddnfslrgealqkaieedkqrglvpv
    fvcatlgttgvcafdclselgpicareglwlhidaayagtaflcpefrgflkgieyadsf
    tfnpskwmmvhfdctgfwvkdkyklqqtfsvnpiylrhansgvatdfmhwqiplsrrfrs
    vklwfvirsfgvknlqahvrhgtemakyfeslvrndpsfeipakrhlglvvfrlkgpnsl
    tenvlkeiakagrlflipatiqdkliirftvtsqfttrddilrdwnlirdaatlilsq
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >4e1oF (F:)
    gplgsmepeeyrergremvdyicqylstvrerrvtpdvqpgylraqlpesapedpdswds
    ifgdieriimpgvvhwqsphmhayypaltswpsllgdmladainclgftwasspactele
    mnvmdwlakmlglpehflhhhpssqgggvlqstvsestliallaarknkilemktsepda
    desslnarlvayasdqahssvekaglislvkmkflpvddnfslrgealqkaieedkqrgl
    vpvfvcatlgttgvcafdclselgpicareglwlhidaayagtaflcpefrgflkgieya
    dsftfnpskwmmvhfdctgfwvkdkyklqqtfsvnpiylrhansgvatdfmhwqiplsrr
    frsvklwfvirsfgvknlqahvrhgtemakyfeslvrndpsfeipakrhlglvvfrlkgp
    nsltenvlkeiakagrlflipatiqdkliirftvtsqfttrddilrdwnlirdaatlils
    q
    

    Sequence, based on observed residues (ATOM records): (download)
    >4e1oF (F:)
    gsmepeeyrergremvdyicqylstvrerrvtpdvqpgylraqlpesapedpdswdsifg
    dieriimpgvvhwqsphmhayypaltswpsllgdmladainclgftwasspactelemnv
    mdwlakmlglpehflhhhpssqgggvlqstvsestliallaarknkilemktsepdades
    slnarlvayasdqahssvekaglislvkmkflpvddnfslrgealqkaieedkqrglvpv
    fvcatlgttgvcafdclselgpicareglwlhidaayagtaflcpefrgflkgieyadsf
    tfnpskwmmvhfdctgfwvkdkyklqqtfsvnpiylrhansgvatdfmhwqiplsrrfrs
    vklwfvirsfgvknlqahvrhgtemakyfeslvrndpsfeipakrhlglvvfrlkgpnsl
    tenvlkeiakagrlflipatiqdkliirftvtsqfttrddilrdwnlirdaatlilsq