PDB entry 4dtg

View 4dtg on RCSB PDB site
Description: Hemostatic effect of a monoclonal antibody mAb 2021 blocking the interaction between FXa and TFPI in a rabbit hemophilia model
Class: blood clotting inhibitor/immune system
Keywords: antibody, inhibitor, blood coagulation, BLOOD CLOTTING INHIBITOR-IMMUNE SYSTEM complex
Deposited on 2012-02-21, released 2012-06-13
The last revision prior to the SCOPe 2.02 freeze date was dated 2012-07-25, with a file datestamp of 2012-07-20.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.198
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'H':
  Compound: Humanized recombinant FAB fragment, FAB 2021, of a murine antibody, heavy chain
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • PDB 4DTG (0-End)
• Chain 'K':
  Compound: tissue factor pathway inhibitor
  Species: Homo sapiens [TaxId:9606]
  Gene: LACI, TFPI, TFPI (AMINO ACIDS 119-178), TFPI1
  Database cross-references and differences (RAF-indexed):
  • Uniprot P10646 (Start-59)
    • expression tag (60)
  Domains in SCOPe 2.02: d4dtgk_
• Chain 'L':
  Compound: Humanized recombinant FAB fragment, FAB 2021, of a murine antibody, light chain
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • PDB 4DTG (0-218)
• Heterogens: GOL, MES, PGE, HOH

PDB Chain Sequences:

• Chain 'H':
  No sequence available.
  
  
• Chain 'K':
  Sequence, based on SEQRES records: (download)
  

  >4dtgK (K:)
  qekpdfcfleedpgicrgyitryfynnqtkqcerfkyggclgnmnnfetleecknicedg
  hhhhhh
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >4dtgK (K:)
  ekpdfcfleedpgicrgyitryfynnqtkqcerfkyggclgnmnnfetleecknicedgh
  

  
  
• Chain 'L':
  No sequence available.