PDB entry 4dsu

View 4dsu on RCSB PDB site
Description: Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity
Class: Hydrolase
Keywords: small G-protein, signaling, Hydrolase
Deposited on 2012-02-19, released 2012-04-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-06-06, with a file datestamp of 2012-06-01.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.162
AEROSPACI score: 0.57 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: GTPase KRas, isoform 2B
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (2-End)
      • expression tag (1)
      • engineered mutation (12)
    Domains in SCOPe 2.08: d4dsua1, d4dsua2
  • Heterogens: GDP, MG, BZI, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4dsuA (A:)
gsteyklvvvgadgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
gqeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcd
lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhkekmskdgkkkkk
ksktkcvim

    Sequence, based on observed residues (ATOM records): (download) 
    >4dsuA (A:)
steyklvvvgadgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
qsamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdlpsr
tvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhkekmskdgkkkkkk