PDB entry 4dst
View 4dst on RCSB PDB site
Description: Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity
Class: Hydrolase
Keywords: Small G-protein, Signaling, Hydrolase
Deposited on
2012-02-19, released
2012-04-04
The last revision prior to the SCOPe 2.04 freeze date was dated
2012-06-06, with a file datestamp of
2012-06-01.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.162
AEROSPACI score: 0.4
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: GTPase KRas, isoform 2B
Species: Homo sapiens [TaxId:9606]
Gene: KRAS, KRAS2, RASK2
Database cross-references and differences (RAF-indexed):
- Uniprot P01116 (2-End)
- expression tag (1)
- engineered mutation (12)
Domains in SCOPe 2.04: d4dsta_ - Heterogens: 9LI, GCP, MG, GOL, EDO, DMS, ACT, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4dstA (A:)
gsteyklvvvgadgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
gqeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcd
lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhkekmskdgkkkkk
ksktkcvim
Sequence, based on observed residues (ATOM records): (download)
>4dstA (A:)
steyklvvvgadgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
qeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdl
psrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhkekmskdgkkkkkk