PDB entry 4dhp

View 4dhp on RCSB PDB site
Description: Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening
Class: protein binding/inhibitor
Keywords: ADAPTER PROTEIN, PHOSPHOPROTEIN BINDING, PROTEIN BINDING-INHIBITOR complex
Deposited on 2012-01-30, released 2013-07-31
The last revision prior to the SCOPe 2.07 freeze date was dated 2013-09-04, with a file datestamp of 2013-08-30.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: 0.156
AEROSPACI score: 0.59 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 14-3-3 protein sigma
    Species: Homo sapiens [TaxId:9606]
    Gene: HME1, SFN
    Database cross-references and differences (RAF-indexed):
    • Uniprot P31947 (4-234)
      • expression tag (0-3)
    Domains in SCOPe 2.07: d4dhpa1, d4dhpa2
  • Heterogens: MG, CL, GOL, Y07, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4dhpA (A:)
    amgsmerasliqkaklaeqaeryedmaafmkgavekgeelsceernllsvayknvvggqr
    aawrvlssieqksneegseekgpevreyrekvetelqgvcdtvlglldshlikeagdaes
    rvfylkmkgdyyrylaevatgddkkriidsarsayqeamdiskkempptnpirlglalnf
    svfhyeianspeeaislakttfdeamadlhtlsedsykdstlimqllrdnltlwt
    

    Sequence, based on observed residues (ATOM records): (download)
    >4dhpA (A:)
    amgsmerasliqkaklaeqaeryedmaafmkgavekgeelsceernllsvayknvvggqr
    aawrvlssieqksngpevreyrekvetelqgvcdtvlglldshlikeagdaesrvfylkm
    kgdyyrylaevatgddkkriidsarsayqeamdiskkempptnpirlglalnfsvfhyei
    anspeeaislakttfdeamadlhtlsedsykdstlimqllrdnltlwt