PDB entry 4dck

View 4dck on RCSB PDB site
Description: Crystal structure of the C-terminus of voltage-gated sodium channel in complex with FGF13 and CaM
Class: transport protein/signaling protein
Keywords: IQ-motif, EF-hand, Voltage-gated Sodium Channel regulation, Nav1.5 CTD binds to FGF13 and CaM. CaM binds to Ca2+., TRANSPORT PROTEIN-TRANSPORT PROTEIN REGULATOR-SIGNALING PROTEIN complex, TRANSPORT PROTEIN-SIGNALING PROTEIN complex
Deposited on 2012-01-17, released 2012-06-27
The last revision prior to the SCOPe 2.07 freeze date was dated 2012-07-25, with a file datestamp of 2012-07-20.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.211
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Sodium channel protein type 5 subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: SCN5A
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: calmodulin
    Species: Homo sapiens [TaxId:9606]
    Gene: CALM1, CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2, CAM3, CAMC, CAMIII
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4dckb_
  • Chain 'C':
    Compound: Fibroblast growth factor 13
    Species: Homo sapiens [TaxId:9606]
    Gene: FGF13, FHF2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4dckc_
  • Heterogens: MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4dckB (B:)
    madqlteeqiaefkeafslfdkdgdgtittkelgtvmrslgqnpteaelqdminevdadg
    ngtidfpefltmmarkmkdtdseeeireafrvfdkdgngyisaaelrhvmtnlgekltde
    evdemireadidgdgqvnyeefvqmmtak
    

    Sequence, based on observed residues (ATOM records): (download)
    >4dckB (B:)
    lteeqiaefkeafslfdittkelgtvmrslgqnpteaelqdminevgtidfpefltmmar
    kmkdtdseeeireafrvfdkdgngyisaaelrhvmtnlgekltdeevdemireadidgdg
    qvnyeefvqmmtak
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >4dckC (C:)
    mallrksysepqlkgivtklysrqgyhlqlqadgtidgtkdedstytlfnlipvglrvva
    iqgvqtklylamnsegylytselftpeckfkesvfenyyvtyssmiyrqqqsgrgwylgl
    nkegeimkgnhvkknkpaahflpkplkvamykepslhdltefsrsgsgtptksrsvsgvl
    nggksmshnest
    

    Sequence, based on observed residues (ATOM records): (download)
    >4dckC (C:)
    pqlkgivtklysrqgyhlqlqadgtidgtkdedstytlfnlipvglrvvaiqgvqtklyl
    amnsegylytselftpeckfkesvfenyyvtyssmiyrqqqsgrgwylglnkegeimkgn
    hvkknkpaahflpkplkvamykepslhd