PDB entry 4d9r
View 4d9r on RCSB PDB site
Description: Inhibiting Alternative Pathway Complement Activation by Targeting the Exosite on Factor D
Class: hydrolase/immune system
Keywords: Factor D, complement, antibody, exosite, Fab, chymotrypsin, protease, HYDROLASE-IMMUNE SYSTEM complex
Deposited on
2012-01-11, released
2012-02-22
The last revision prior to the SCOPe 2.06 freeze date was dated
2012-05-02, with a file datestamp of
2012-04-27.
Experiment type: XRAY
Resolution: 2.42 Å
R-factor: 0.215
AEROSPACI score: 0.32
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: complement factor d
Species: Homo sapiens [TaxId:9606]
Gene: CFD, DF, Factor D, PFD
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d4d9ra_ - Chain 'B':
Compound: complement factor d
Species: Homo sapiens [TaxId:9606]
Gene: CFD, DF, Factor D, PFD
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d4d9rb_ - Chain 'D':
Compound: Fab light chain
Species: Homo sapiens [TaxId:9606]
Gene: IGKC
Database cross-references and differences (RAF-indexed):
- PDB 4D9R (0-103)
- Uniprot P01834 (108-End)
Domains in SCOPe 2.06: d4d9rd1, d4d9rd2 - Chain 'E':
Compound: Fab heavy chain
Species: Homo sapiens [TaxId:9606]
Gene: IGHG1
Database cross-references and differences (RAF-indexed):
- PDB 4D9R (0-109)
- Uniprot P01857 (115-End)
- Chain 'H':
Compound: Fab heavy chain
Species: Homo sapiens [TaxId:9606]
Gene: IGHG1
Database cross-references and differences (RAF-indexed):
- PDB 4D9R (0-109)
- Uniprot P01857 (115-217)
- Chain 'L':
Compound: Fab light chain
Species: Homo sapiens [TaxId:9606]
Gene: IGKC
Database cross-references and differences (RAF-indexed):
- PDB 4D9R (0-103)
- Uniprot P01834 (108-213)
Domains in SCOPe 2.06: d4d9rl1, d4d9rl2 - Heterogens: CL, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>4d9rA (A:)
ilggreaeaharpymasvqlngahlcggvlvaeqwvlsaahcledaadgkvqvllgahsl
sqpepskrlydvlravphpdsqpdtidhdllllqlsekatlgpavrplpwqrvdrdvapg
tlcdvagwgivnhagrrpdslqhvllpvldratcnrrthhdgaiterlmcaesnrrdsck
gdsggplvcggvlegvvtsgsrvcgnrkkpgiytrvasyaawidsvla
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>4d9rB (B:)
ilggreaeaharpymasvqlngahlcggvlvaeqwvlsaahcledaadgkvqvllgahsl
sqpepskrlydvlravphpdsqpdtidhdllllqlsekatlgpavrplpwqrvdrdvapg
tlcdvagwgivnhagrrpdslqhvllpvldratcnrrthhdgaiterlmcaesnrrdsck
gdsggplvcggvlegvvtsgsrvcgnrkkpgiytrvasyaawidsvla
- Chain 'D':
Sequence, based on SEQRES records: (download)
>4d9rD (D:)
diqvtqspsslsasvgdrvtitcitstdidddmnwyqqkpgkvpkllisggntlrpgvps
rfsgsgsgtdftltisslqpedvatyyclqsdslpytfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec
Sequence, based on observed residues (ATOM records): (download)
>4d9rD (D:)
diqvtqspsslsasvgdrvtitcitstdidddmnwyqqkpgkvpkllisggntlrpgvps
rfsgsgsgtdftltisslqpedvatyyclqsdslpytfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrge
- Chain 'E':
No sequence available.
- Chain 'H':
No sequence available.
- Chain 'L':
Sequence; same for both SEQRES and ATOM records: (download)
>4d9rL (L:)
diqvtqspsslsasvgdrvtitcitstdidddmnwyqqkpgkvpkllisggntlrpgvps
rfsgsgsgtdftltisslqpedvatyyclqsdslpytfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec