PDB entry 4cue

View 4cue on RCSB PDB site
Description: Human Notch1 EGF domains 11-13 mutant T466V
Class: transcription
Keywords: transcription, metal-binding, transmembrane, developmental, protein, notch signaling pathway, differentiation, phosphorylation, egf-like domain, regulation, receptor, activator, ank repeat, signalling, glycoprotein, extracellular, egf, jagged, nucleus, membrane
Deposited on 2014-03-18, released 2014-05-21
The last revision prior to the SCOPe 2.04 freeze date was dated 2014-06-04, with a file datestamp of 2014-05-30.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.2608
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Neurogenic locus notch homolog protein 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P46531 (Start-117)
      • expression tag (118-124)
      • engineered mutation (57)
    Domains in SCOPe 2.04: d4cuea1, d4cuea2, d4cuea3
  • Heterogens: CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4cueA (A:)
    saqdvdecslganpcehagkcintlgsfecqclqgytgprceidvnecvsnpcqndavcl
    dqigefqcicmpgyegvhcevntdecasspclhngrcldkinefqcecptgftghlcqvd
    lhhildaqkmvwnhr
    

    Sequence, based on observed residues (ATOM records): (download)
    >4cueA (A:)
    dvdecslganpcehagkcintlgsfecqclqgytgprceidvnecvsnpcqndavcldqi
    gefqcicmpgyegvhcevntdecasspclhngrcldkinefqcecptgftghlcqvdlhh
    il