PDB entry 4ctc

View 4ctc on RCSB PDB site
Description: Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor 7-amino-3-cyclopropyl-12-fluoro-1,10,16-trimethyl-16,17- dihydro-1H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecin-15(10H)-one
Class: transferase
Keywords: transferase, inhibitor
Deposited on 2014-03-12, released 2014-05-28
The last revision prior to the SCOPe 2.06 freeze date was dated 2014-06-25, with a file datestamp of 2014-06-20.
Experiment type: XRAY
Resolution: 2.03 Å
R-factor: 0.1938
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ALK tyrosine kinase receptor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4ctca_
  • Heterogens: J99, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4ctcA (A:)
    mahhhhhhnpnycfagktssisdlkevprknitlirglghgafgevyegqvsgmpndpsp
    lqvavktlpevcseqdeldflmealiiskfnhqnivrcigvslqslprfillelmaggdl
    ksflretrprpsqpsslamldllhvardiacgcqyleenhfihrdiaarnclltcpgpgr
    vakigdfgmardiyrasyyrkggcamlpvkwmppeafmegiftsktdtwsfgvllweifs
    lgympypsksnqevlefvtsggrmdppkncpgpvyrimtqcwqhqpedrpnfaiilerie
    yctqdpdvintalpieygplveeeekv
    

    Sequence, based on observed residues (ATOM records): (download)
    >4ctcA (A:)
    pnycfagktssisdlkevprknitlirglggevyegqvplqvavktlpevcseqdeldfl
    mealiiskfnhqnivrcigvslqslprfillelmaggdlksflretrprpsqpsslamld
    llhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfgmardiggcamlpv
    kwmppeafmegiftsktdtwsfgvllweifslgympypsksnqevlefvtsggrmdppkn
    cpgpvyrimtqcwqhqpedrpnfaiilerieyctqdpdvintalpieyg