PDB entry 4cmt

View 4cmt on RCSB PDB site
Description: Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor 3-((1R)-1-(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)ethoxy)- 5-(3-(methylsulfonyl)phenyl)pyridin-2-amine
Class: transferase
Keywords: transferase, receptor tyrosine kinase, inhibitor
Deposited on 2014-01-17, released 2014-05-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-05-08, with a file datestamp of 2019-05-03.
Experiment type: XRAY
Resolution: 1.73 Å
R-factor: N/A
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ALK tyrosine kinase receptor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4cmta_
  • Heterogens: GWH, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4cmtA (A:)
mahhhhhhnpnycfagktssisdlkevprknitlirglghgafgevyegqvsgmpndpsp
lqvavktlpevcseqdeldflmealiiskfnhqnivrcigvslqslprfillelmaggdl
ksflretrprpsqpsslamldllhvardiacgcqyleenhfihrdiaarnclltcpgpgr
vakigdfgmardiyrasyyrkggcamlpvkwmppeafmegiftsktdtwsfgvllweifs
lgympypsksnqevlefvtsggrmdppkncpgpvyrimtqcwqhqpedrpnfaiilerie
yctqdpdvintalpieygplveeeekv

    Sequence, based on observed residues (ATOM records): (download) 
    >4cmtA (A:)
npnycfagktssisdlkevprknitlirglghgevyegqvsplqvavktlpevcseqdel
dflmealiiskfnhqnivrcigvslqslprfillelmaggdlksflretrprpsqslaml
dllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfgmardiyramlpv
kwmppeafmegiftsktdtwsfgvllweifslgympypsksnqevlefvtsggrmdppkn
cpgpvyrimtqcwqhqpedrpnfaiilerieyctqdpdvintalpiey