PDB entry 4bw4

View 4bw4 on RCSB PDB site
Description: The first bromodomain of human BRD4 in complex with 3,5 dimethylisoxaxole ligand
Class: transcription
Keywords: transcription, inhibitor, histone, epigenetic reader, antagonist
Deposited on 2013-06-29, released 2013-09-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-03-19, with a file datestamp of 2014-03-14.
Experiment type: XRAY
Resolution: 1.67 Å
R-factor: 0.19019
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bromodomain-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60885 (2-126)
      • expression tag (0-1)
    Domains in SCOPe 2.08: d4bw4a1, d4bw4a2
  • Heterogens: 9B6, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4bw4A (A:)
    smnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
    ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
    nelptee