PDB entry 4bti

View 4bti on RCSB PDB site
Description: factor Xa in complex with the dual thrombin-FXa inhibitor 58.
Class: hydrolase
Keywords: hydrolase, sar107375, factor xa inhibitor, thrombin inhibitor, chlorothiophene p1 fragment, s3 subsite, microsomes stability, oral antithrombotic, dual inhibitor, IV antithrombotic
Deposited on 2013-06-18, released 2013-12-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-05-08, with a file datestamp of 2019-05-03.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: coagulation factor x heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4btia_
  • Chain 'B':
    Compound: coagulation factor x light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4btib_
  • Chain 'E':
    Compound: coagulation factor x heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4btie_
  • Chain 'F':
    Compound: coagulation factor x light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4btif_
  • Heterogens: CA, 7R9, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4btiA (A:)
ykdgdqcetspcqnqgkckdglgeytctclegfegkncelftrklcsldngdcdqfchee
qnsvvcscargytladngkaciptgpypcgkqtler

    Sequence, based on observed residues (ATOM records): (download) 
    >4btiA (A:)
rklcsldngdcdqfcheeqnsvvcscargytladngkaciptgpypcgkqtler

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4btiB (B:)
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktrglpka
kshapevitssplk

    Sequence, based on observed residues (ATOM records): (download) 
    >4btiB (B:)
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktr

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4btiE (E:)
ykdgdqcetspcqnqgkckdglgeytctclegfegkncelftrklcsldngdcdqfchee
qnsvvcscargytladngkaciptgpypcgkqtler

    Sequence, based on observed residues (ATOM records): (download) 
    >4btiE (E:)
rklcsldngdcdqfcheeqnsvvcscargytladngkaciptgpypcgkqtler

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4btiF (F:)
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktrglpka
kshapevitssplk

    Sequence, based on observed residues (ATOM records): (download) 
    >4btiF (F:)
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktr