PDB entry 4bl3

View 4bl3 on RCSB PDB site
Description: Crystal structure of PBP2a clinical mutant N146K from MRSA
Class: hydrolase
Keywords: hydrolase, mrsa, allosteric site, b-lactam antibiotics
Deposited on 2013-04-30, released 2014-05-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: penicillin binding protein 2 prime
    Species: Staphylococcus aureus [TaxId:1280]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q54113 (0-639)
      • engineered mutation (120)
    Domains in SCOPe 2.08: d4bl3a1, d4bl3a2, d4bl3a3
  • Chain 'B':
    Compound: penicillin binding protein 2 prime
    Species: Staphylococcus aureus [TaxId:1280]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q54113 (0-639)
      • engineered mutation (120)
    Domains in SCOPe 2.08: d4bl3b1, d4bl3b2, d4bl3b3
  • Heterogens: CD, CL, MUR, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4bl3A (A:)
kdkeinntidaiedknfkqvykdssyisksdngevemterpikiynslgvkdiniqdrki
kkvsknkkrvdaqykiktnygnidrnvqfnfvkedgmwkldwdhsviipgmqkdqsihie
klksergkildrnnvelantgtayeigivpknvskkdykaiakelsisedyikqqmdqnw
vqddtfvplktvkkmdeylsdfakkfhlttnetesrnyplgkatshllgyvgpinseelk
qkeykgykddavigkkgleklydkklqhedgyrvtivddnsntiahtliekkkkdgkdiq
ltidakvqksiynnmkndygsgtaihpqtgellalvstpsydvypfmygmsneeynklte
dkkepllnkfqittspgstqkiltamiglnnktlddktsykidgkgwqkdkswggynvtr
yevvngnidlkqaiessdniffarvalelgskkfekgmkklgvgedipsdypfynaqisn
knldneilladsgygqgeilinpvqilsiysalenngninaphllkdtknkvwkkniisk
eninlltdgmqqvvnkthkediyrsyanligksgtaelkmkqgrqigwfisydkdnpnmm
mainvkdvqdkgmasynakisgkvydelyengnkkydide

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4bl3B (B:)
kdkeinntidaiedknfkqvykdssyisksdngevemterpikiynslgvkdiniqdrki
kkvsknkkrvdaqykiktnygnidrnvqfnfvkedgmwkldwdhsviipgmqkdqsihie
klksergkildrnnvelantgtayeigivpknvskkdykaiakelsisedyikqqmdqnw
vqddtfvplktvkkmdeylsdfakkfhlttnetesrnyplgkatshllgyvgpinseelk
qkeykgykddavigkkgleklydkklqhedgyrvtivddnsntiahtliekkkkdgkdiq
ltidakvqksiynnmkndygsgtaihpqtgellalvstpsydvypfmygmsneeynklte
dkkepllnkfqittspgstqkiltamiglnnktlddktsykidgkgwqkdkswggynvtr
yevvngnidlkqaiessdniffarvalelgskkfekgmkklgvgedipsdypfynaqisn
knldneilladsgygqgeilinpvqilsiysalenngninaphllkdtknkvwkkniisk
eninlltdgmqqvvnkthkediyrsyanligksgtaelkmkqgrqigwfisydkdnpnmm
mainvkdvqdkgmasynakisgkvydelyengnkkydide

    Sequence, based on observed residues (ATOM records): (download) 
    >4bl3B (B:)
kdkeinntidaiedknfkqvykdssyisksdngevemterpikiynslgvkdiniqdrki
kkvsknkkrvdaqykiktnygnidrnvqfnfvkedgmwkldwdhsviipgmqkdqsihie
klksergkildrnnvelantgtayeigivpknvskkdykaiakelsisedyikqqmdqnw
vqddtfvplktvkkmdeylsdfakkfhlttnetesrnyplgkatshllgyvgpinseelk
qkeykgykddavigkkgleklydkklqhedgyrvtivddnsntiahtliekkkkdgkdiq
ltidakvqksiynnmkndygsgtaihpqtgellalvstpsydvypfmygmsneeynklte
dkkepllnkfqittspgstqkiltamiglnnktlddktsykidgkgwqkdkswggynvtr
yevvngnidlkqaiessdniffarvalelgskkfekgmkklgvgedipsdypfynaqisn
knldneilladsgygqgeilinpvqilsiysalenngninaphllkdtknkvwkkniisk
eninlltdgmqqvvnkthkediyrsyanligksgtaelkmkgrqigwfisydkdnpnmmm
ainvkdvqdkgmasynakisgkvydelyengnkkydide