PDB entry 4bl2

View 4bl2 on RCSB PDB site
Description: Crystal structure of PBP2a clinical mutant E150K from MRSA
Class: hydrolase
Keywords: hydrolase, penicillin binding proteins, b-lactum antibiotics
Deposited on 2013-04-30, released 2014-05-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-07-05, with a file datestamp of 2017-06-30.
Experiment type: XRAY
Resolution: 2.72 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: penicillin binding protein 2 prime
    Species: Staphylococcus aureus [TaxId:1280]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q54113 (0-642)
      • engineered mutation (124)
    Domains in SCOPe 2.08: d4bl2a1, d4bl2a2, d4bl2a3
  • Chain 'B':
    Compound: penicillin binding protein 2 prime
    Species: Staphylococcus aureus [TaxId:1280]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q54113 (Start-642)
      • engineered mutation (124)
    Domains in SCOPe 2.08: d4bl2b1, d4bl2b2, d4bl2b3
  • Heterogens: CD, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4bl2A (A:)
kdkeinntidaiedknfkqvykdssyisksdngevemterpikiynslgvkdiniqdrki
kkvsknkkrvdaqykiktnygnidrnvqfnfvkedgmwkldwdhsviipgmqkdqsihie
nlkskrgkildrnnvelantgtayeigivpknvskkdykaiakelsisedyikqqmdqnw
vqddtfvplktvkkmdeylsdfakkfhlttnetesrnyplgkatshllgyvgpinseelk
qkeykgykddavigkkgleklydkklqhedgyrvtivddnsntiahtliekkkkdgkdiq
ltidakvqksiynnmkndygsgtaihpqtgellalvstpsydvypfmygmsneeynklte
dkkepllnkfqittspgstqkiltamiglnnktlddktsykidgkgwqkdkswggynvtr
yevvngnidlkqaiessdniffarvalelgskkfekgmkklgvgedipsdypfynaqisn
knldneilladsgygqgeilinpvqilsiysalenngninaphllkdtknkvwkkniisk
eninlltdgmqqvvnkthkediyrsyanligksgtaelkmkqgetgrqigwfisydkdnp
nmmmainvkdvqdkgmasynakisgkvydelyengnkkydide

    Sequence, based on observed residues (ATOM records): (download) 
    >4bl2A (A:)
kdkeinntidaiedknfkqvykdssyisksdngevemterpikiynslgvkdiniqdrki
kkvsknkkrvdaqykiktnygnidrnvqfnfvkedgmwkldwdhsviipgmqkdqsihie
nlkskrgkildrnnvelantgtayeigivpknvskkdykaiakelsisedyikqqmdqnw
vqddtfvplktvkkmdeylsdfakkfhlttnetesrnyplgkatshllgyvgpinseelk
qkeykgykddavigkkgleklydkklqhedgyrvtivddnsntiahtliekkkkdgkdiq
ltidakvqksiynnmkndygsgtaihpqtgellalvstpsydvypfmygmsneeynklte
dkkepllnkfqittspgstqkiltamiglnnktlddktsykidgkgwqkdkswggynvtr
yevvngnidlkqaiessdniffarvalelgskkfekgmkklgvgedipsdypfynaqisn
knldneilladsgygqgeilinpvqilsiysalenngninaphllkdtknkvwkkniisk
eninlltdgmqqvvnkthkediyrsyanligksgtaelkgrqigwfisydkdnpnmmmai
nvkdvqdkgmasynakisgkvydelyengnkkydide

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4bl2B (B:)
kdkeinntidaiedknfkqvykdssyisksdngevemterpikiynslgvkdiniqdrki
kkvsknkkrvdaqykiktnygnidrnvqfnfvkedgmwkldwdhsviipgmqkdqsihie
nlkskrgkildrnnvelantgtayeigivpknvskkdykaiakelsisedyikqqmdqnw
vqddtfvplktvkkmdeylsdfakkfhlttnetesrnyplgkatshllgyvgpinseelk
qkeykgykddavigkkgleklydkklqhedgyrvtivddnsntiahtliekkkkdgkdiq
ltidakvqksiynnmkndygsgtaihpqtgellalvstpsydvypfmygmsneeynklte
dkkepllnkfqittspgstqkiltamiglnnktlddktsykidgkgwqkdkswggynvtr
yevvngnidlkqaiessdniffarvalelgskkfekgmkklgvgedipsdypfynaqisn
knldneilladsgygqgeilinpvqilsiysalenngninaphllkdtknkvwkkniisk
eninlltdgmqqvvnkthkediyrsyanligksgtaelkmkqgetgrqigwfisydkdnp
nmmmainvkdvqdkgmasynakisgkvydelyengnkkydide

    Sequence, based on observed residues (ATOM records): (download) 
    >4bl2B (B:)
dkeinntidaiedknfkqvykdssyisksdngevemterpikiynslgvkdiniqdrkik
kvsknkkrvdaqykiktnygnidrnvqfnfvkedgmwkldwdhsviipgmqkdqsihien
lkskrgkildrnnvelantgtayeigivpknvskkdykaiakelsisedyikqqmdqnwv
qddtfvplktvkkmdeylsdfakkfhlttnetesrnyplgkatshllgyvgpinseelkq
keykgykddavigkkgleklydkklqhedgyrvtivddnsntiahtliekkkkdgkdiql
tidakvqksiynnmkndygsgtaihpqtgellalvstpsydvypfmygmsneeynklted
kkepllnkfqittspgstqkiltamiglnnktlddktsykidgkgwqkdkswggynvtry
evvngnidlkqaiessdniffarvalelgskkfekgmkklgvgedipsdypfynaqisnk
nldneilladsgygqgeilinpvqilsiysalenngninaphllkdtknkvwkkniiske
ninlltdgmqqvvnkthkediyrsyanligksgtaelktgrqigwfisydkdnpnmmmai
nvkdvqdkgmasynakisgkvydelyengnkkydide