PDB entry 4bcq

View 4bcq on RCSB PDB site
Description: Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor
Class: transferase/cell cycle
Keywords: transferase-cell cycle complex, cdk-cyclin complex, cyclin a, cyclin- dependent kinase 2, structure-based drug design
Deposited on 2012-10-02, released 2013-01-09
The last revision prior to the SCOPe 2.06 freeze date was dated 2013-02-27, with a file datestamp of 2013-02-22.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.2171
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cyclin-dependent kinase 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P24941 (3-End)
      • expression tag (0-2)
    Domains in SCOPe 2.06: d4bcqa1, d4bcqa2
  • Chain 'B':
    Compound: Cyclin-A2
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30274 (Start-260)
      • expression tag (261)
      • conflict (132)
      • conflict (140)
      • conflict (206-207)
      • conflict (216)
      • conflict (220)
      • conflict (229)
    Domains in SCOPe 2.06: d4bcqb1, d4bcqb2, d4bcqb3
  • Chain 'C':
    Compound: cyclin-dependent kinase 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P24941 (3-End)
      • expression tag (2)
    Domains in SCOPe 2.06: d4bcqc1, d4bcqc2
  • Chain 'D':
    Compound: Cyclin-A2
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30274
      • conflict (132)
      • conflict (140)
      • conflict (206-207)
      • conflict (215)
      • conflict (219)
      • conflict (229)
    Domains in SCOPe 2.06: d4bcqd1, d4bcqd2
  • Heterogens: TJF, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4bcqA (A:)
pgsmenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllke
lnhpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglaf
chshrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgc
kyystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdyk
psfpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlr
l

    Sequence, based on observed residues (ATOM records): (download) 
    >4bcqA (A:)
pgsmenfqkvekigvvykarnkltgevvalkkirldtetegvpstaireisllkelnhpn
ivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshr
vlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyyst
avdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpk
warqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvph

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4bcqB (B:)
svnevpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqne
tlhlavnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkq
vlrmehlvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylky
lpsviaaaafhlalytvtgqswpeslirktgytletskpcmldlhqtylkapqhaqqsir
ekyknskyhgvsllnppetlnl

    Sequence, based on observed residues (ATOM records): (download) 
    >4bcqB (B:)
pdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhla
vnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvlrme
hlvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylkylpsvi
aaaafhlalytvtgqswpeslirktgytletskpcmldlhqtylkapqhaqqsirekykn
skyhgvsllnppetlnl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4bcqC (C:)
pgsmenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllke
lnhpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglaf
chshrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgc
kyystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdyk
psfpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlr
l

    Sequence, based on observed residues (ATOM records): (download) 
    >4bcqC (C:)
smenfqkvekigeygvvykarnkltgevvalkkirldtetegvpstaireisllkelnhp
nivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchsh
rvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyys
tavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfp
kwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvp

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4bcqD (D:)
svnevpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqne
tlhlavnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkq
vlrmehlvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylky
lpsviaaaafhlalytvtgqswpeslirktgytleslkpmlldlhqtylkapqhaqqsir
ekyknskyhgvsllnppetlnv

    Sequence, based on observed residues (ATOM records): (download) 
    >4bcqD (D:)
pdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhla
vnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvlrme
hlvlkvltfdlaaptvnqfltqyflhqanckveslamflgelslidadpylkylpsviaa
aafhlalytvtgqswpeslirktgytleslkpmlldlhqtylkapqhaqqsirekyknsk
yhgvsllnppetln