PDB entry 4bbe

View 4bbe on RCSB PDB site
Description: Aminoalkylpyrimidine Inhibitor Complexes with JAK2
Class: transferase
Keywords: transferase, inhibitor
Deposited on 2012-09-21, released 2012-11-21
The last revision prior to the SCOPe 2.06 freeze date was dated 2012-12-19, with a file datestamp of 2012-12-14.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.3443
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60674
      • engineered mutation (139)
    Domains in SCOPe 2.06: d4bbea_
  • Chain 'B':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60674
      • engineered mutation (139)
    Domains in SCOPe 2.06: d4bbeb_
  • Chain 'C':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60674
      • engineered mutation (139)
    Domains in SCOPe 2.06: d4bbec_
  • Chain 'D':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60674
      • engineered mutation (139)
    Domains in SCOPe 2.06: d4bbed_
  • Heterogens: 3O4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4bbeA (A:)
gsrdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfe
reieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqy
tsqickgmeylgtkryihrnlatrnilvenenrvkigdfgltkvlpqdkeyykvkepges
pifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivf
hliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmagef

    Sequence, based on observed residues (ATOM records): (download) 
    >4bbeA (A:)
ptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfereie
ilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqytsqi
ckgmeylgtkryihrnlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespifw
yapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhlie
llknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqird

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4bbeB (B:)
gsrdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfe
reieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqy
tsqickgmeylgtkryihrnlatrnilvenenrvkigdfgltkvlpqdkeyykvkepges
pifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivf
hliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmagef

    Sequence, based on observed residues (ATOM records): (download) 
    >4bbeB (B:)
ptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfereie
ilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqytsqi
ckgmeylgtkryihrnlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespifw
yapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhlie
llknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqird

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4bbeC (C:)
gsrdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfe
reieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqy
tsqickgmeylgtkryihrnlatrnilvenenrvkigdfgltkvlpqdkeyykvkepges
pifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivf
hliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmagef

    Sequence, based on observed residues (ATOM records): (download) 
    >4bbeC (C:)
ptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfereie
ilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqytsqi
ckgmeylgtkryihrnlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespifw
yapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhlie
llknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqird

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4bbeD (D:)
gsrdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfe
reieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqy
tsqickgmeylgtkryihrnlatrnilvenenrvkigdfgltkvlpqdkeyykvkepges
pifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivf
hliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmagef

    Sequence, based on observed residues (ATOM records): (download) 
    >4bbeD (D:)
ptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfereie
ilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqytsqi
ckgmeylgtkryihrnlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespifw
yapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhlie
llknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqird