PDB entry 4b8m

View 4b8m on RCSB PDB site
Description: Aurora B kinase in complex with VX-680
Class: cell cycle
Keywords: cell cycle, cancer
Deposited on 2012-08-28, released 2013-07-10
The last revision prior to the SCOPe 2.03 freeze date was dated 2013-07-10, with a file datestamp of 2013-07-05.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: 0.19303
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: aurora kinase b-a
    Species: Xenopus laevis [TaxId:8355]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4b8ma_
  • Chain 'B':
    Compound: aurora kinase b-a
    Species: Xenopus laevis [TaxId:8355]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4b8mb_
  • Chain 'C':
    Compound: inner centromere protein a
    Species: Xenopus laevis [TaxId:8355]
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: inner centromere protein a
    Species: Xenopus laevis [TaxId:8355]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: VX6, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4b8mA (A:)
    atalaempkrkftiddfdigrplgkgkfgnvylarekqnkfimalkvlfksqlekegveh
    qlrreieiqshlrhpnilrmynyfhdrkriylmlefaprgelykelqkhgrfdeqrsatf
    meeladalhycherkvihrdikpenllmgykgelkiadfgwsvhapslrrrtmcgtldyl
    ppemiegkthdekvdlwcagvlcyeflvgmppfdspshtethrrivnvdlkfppflsdgs
    kdliskllryhppqrlplkgvmehpwvkansrrvlppvyqstqskd
    

    Sequence, based on observed residues (ATOM records): (download)
    >4b8mA (A:)
    kftiddfdigrplgkgkfgnvylarekqnkfimalkvlfksqlekegvehqlrreieiqs
    hlrhpnilrmynyfhdrkriylmlefaprgelykelqkhgrfdeqrsatfmeeladalhy
    cherkvihrdikpenllmgykgelkiadfgwsvhapslrrrtmcgtldylppemiegkth
    dekvdlwcagvlcyeflvgmppfdspshtethrrivnvdlkfppflsdgskdliskllry
    hppqrlplkgvmehpwvkansrrvlppvyqs
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4b8mB (B:)
    atalaempkrkftiddfdigrplgkgkfgnvylarekqnkfimalkvlfksqlekegveh
    qlrreieiqshlrhpnilrmynyfhdrkriylmlefaprgelykelqkhgrfdeqrsatf
    meeladalhycherkvihrdikpenllmgykgelkiadfgwsvhapslrrrtmcgtldyl
    ppemiegkthdekvdlwcagvlcyeflvgmppfdspshtethrrivnvdlkfppflsdgs
    kdliskllryhppqrlplkgvmehpwvkansrrvlppvyqstqskd
    

    Sequence, based on observed residues (ATOM records): (download)
    >4b8mB (B:)
    talaempkrkftiddfdigrplgkgkfgnvylarekqnkfimalkvlfksqlekegvehq
    lrreieiqshlrhpnilrmynyfhdrkriylmlefaprgelykelqkhgrfdeqrsatfm
    eeladalhycherkvihrdikpenllmgykgelkiadfgwsvhapslrrrtmcgtldylp
    pemiegkthdekvdlwcagvlcyeflvgmppfdspshtethrrivnvdlkfppflsdgsk
    dliskllryhppqrlplkgvmehpwvkansrrvlppvyqs
    

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.