PDB entry 4az1

View 4az1 on RCSB PDB site
Description: Crystal structure of the Trypanosoma cruzi protein tyrosine phosphatase TcPTP1, a potential therapeutic target for Chagas' disease
Class: hydrolase
Keywords: hydrolase, drug design
Deposited on 2012-06-22, released 2012-11-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-02-13, with a file datestamp of 2013-02-08.
Experiment type: XRAY
Resolution: 2.18 Å
R-factor: 0.1914
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: tyrosine specific protein phosphatase
    Species: Trypanosoma cruzi [TaxId:5693]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4az1a_
  • Chain 'B':
    Compound: tyrosine specific protein phosphatase
    Species: Trypanosoma cruzi [TaxId:5693]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4az1b_
  • Heterogens: EDO, FMT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4az1A (A:)
mndsncfpftklsvqaqyervqrefslllrqedprsisfatslknrhknryldilaneat
lypqvtdapgastpyyingnlidldlphkfvacqapvvqgipdflamlyekkislvimvt
kleeggfvkadrywpeergsgsiavsgncgltisedpgkayevedelkitrrylilqrad
epphkftqvqytgwpdhgipqsatslealltnvknspttvpvvvhcsagigrtgtligay
aalthlergtltdttvydvvsamrrqrfgmvqrmeqyfviyltlmcrlgvdikalvglln
sr

    Sequence, based on observed residues (ATOM records): (download) 
    >4az1A (A:)
dsncfpftklsvqaqyervqrefslllrqedprsisfatslknrhknryldilaneatly
pqvtdstpyyingnlidldlphkfvacqapvvqgipdflamlyekkislvimvtkleegg
fvkadrywpeergsgsiavsgncgltisedpgkayevedelkitrrylilqradepphkf
tqvqytgwpdhgipqsatslealltnvknspttvpvvvhcsagigrtgtligayaalthl
ergtltdttvydvvsamrrqrfgmvqrmeqyfviyltlmcrlgvdikalvglln

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4az1B (B:)
mndsncfpftklsvqaqyervqrefslllrqedprsisfatslknrhknryldilaneat
lypqvtdapgastpyyingnlidldlphkfvacqapvvqgipdflamlyekkislvimvt
kleeggfvkadrywpeergsgsiavsgncgltisedpgkayevedelkitrrylilqrad
epphkftqvqytgwpdhgipqsatslealltnvknspttvpvvvhcsagigrtgtligay
aalthlergtltdttvydvvsamrrqrfgmvqrmeqyfviyltlmcrlgvdikalvglln
sr

    Sequence, based on observed residues (ATOM records): (download) 
    >4az1B (B:)
sncfpftklsvqaqyervqrefslllrqedprsisfatslknrhknryldilaneatlyp
qvtdapgastpyyingnlidldlphkfvacqapvvqgipdflamlyekkislvimvtkle
eggfvkadrywpeergsgsiavsgncgltisedpgkayevedelkitrrylilqradepp
hkftqvqytgwpdhgipqsatslealltnvknspttvpvvvhcsagigrtgtligayaal
thlergtltdttvydvvsamrrqrfgmvqrmeqyfviyltlmcrlgvdikal