PDB entry 4ay9

View 4ay9 on RCSB PDB site
Description: Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor
Class: hormone/receptor
Keywords: hormone-receptor complex, leucine-rich repeats, lrr, gpcr
Deposited on 2012-06-19, released 2012-08-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: glycoprotein hormones, alpha polypeptide
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4ay9a_
  • Chain 'B':
    Compound: follitropin subunit beta
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4ay9b_
  • Chain 'D':
    Compound: glycoprotein hormones, alpha polypeptide
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4ay9d_
  • Chain 'E':
    Compound: follitropin subunit beta
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4ay9e_
  • Chain 'G':
    Compound: glycoprotein hormones, alpha polypeptide
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4ay9g_
  • Chain 'H':
    Compound: follitropin subunit beta
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4ay9h_
  • Chain 'X':
    Compound: follicle-stimulating hormone receptor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23945
      • conflict (171)
  • Chain 'Y':
    Compound: follicle-stimulating hormone receptor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23945
      • conflict (171)
  • Chain 'Z':
    Compound: follicle-stimulating hormone receptor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23945
      • conflict (171)
  • Heterogens: NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4ay9A (A:)
apdvqdcpectlqenplfsqpgapilqcmgccfsrayptplrskktmlvqknvtsestcc
vaksynrvtvmggfkvenhtachcstcyyhks

    Sequence, based on observed residues (ATOM records): (download) 
    >4ay9A (A:)
qdcpectlqenplfsqpgapilqcmgccfsrayptplrskktmlvqknvtsestccvaks
ynrvtvmggfkvenhtachcstcyyhks

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4ay9B (B:)
nsceltnitiaiekeecrfcisinttwcagycytrdlvykdparpkiqktctfkelvyet
vrvpgcahhadslytypvatqchcgkcdsdstdctvrglgpsycsfgemke

    Sequence, based on observed residues (ATOM records): (download) 
    >4ay9B (B:)
nsceltnitiaiekeecrfcisinttwcagycytrdlvykdparpkiqktctfkelvyet
vrvpgcahhadslytypvatqchcgkcdsdstdctvrglgpsycsfg

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4ay9D (D:)
apdvqdcpectlqenplfsqpgapilqcmgccfsrayptplrskktmlvqknvtsestcc
vaksynrvtvmggfkvenhtachcstcyyhks

    Sequence, based on observed residues (ATOM records): (download) 
    >4ay9D (D:)
vqdcpectlqenplfsqpgapilqcmgccfsrayptplrskktmlvqknvtsestccvak
synrvtvmggfkvenhtachcstcyyhks

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4ay9E (E:)
nsceltnitiaiekeecrfcisinttwcagycytrdlvykdparpkiqktctfkelvyet
vrvpgcahhadslytypvatqchcgkcdsdstdctvrglgpsycsfgemke

    Sequence, based on observed residues (ATOM records): (download) 
    >4ay9E (E:)
nsceltnitiaiekeecrfcisinttwcagycytrdlvykdparpkiqktctfkelvyet
vrvpgcahhadslytypvatqchcgkcdsdstdctvrglgpsycsfg

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >4ay9G (G:)
apdvqdcpectlqenplfsqpgapilqcmgccfsrayptplrskktmlvqknvtsestcc
vaksynrvtvmggfkvenhtachcstcyyhks

    Sequence, based on observed residues (ATOM records): (download) 
    >4ay9G (G:)
qdcpectlqenplfsqpgapilqcmgccfsrayptplrskktmlvqknvtsestccvaks
ynrvtvmggfkvenhtachcstcyyhks

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >4ay9H (H:)
nsceltnitiaiekeecrfcisinttwcagycytrdlvykdparpkiqktctfkelvyet
vrvpgcahhadslytypvatqchcgkcdsdstdctvrglgpsycsfgemke

    Sequence, based on observed residues (ATOM records): (download) 
    >4ay9H (H:)
nsceltnitiaiekeecrfcisinttwcagycytrdlvykdparpkiqktctfkelvyet
vrvpgcahhadslytypvatqchcgkcdsdstdctvrglgpsycsfg

  • Chain 'X':
    No sequence available.

  • Chain 'Y':
    No sequence available.

  • Chain 'Z':
    No sequence available.