PDB entry 4aw1

View 4aw1 on RCSB PDB site
Description: Human PDK1 Kinase Domain in Complex with Allosteric Compound PS210 Bound to the PIF-Pocket
Class: transferase
Keywords: transferase, allosteric regulation, allosteric site, phosphorylation, agc protein kinase
Deposited on 2012-05-30, released 2012-10-03
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-10-10, with a file datestamp of 2012-10-05.
Experiment type: XRAY
Resolution: 1.68 Å
R-factor: 0.1652
AEROSPACI score: 0.58 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3-phosphoinositide-dependent protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O15530 (Start-310)
      • engineered mutation (239)
      • engineered mutation (243)
    Domains in SCOPe 2.08: d4aw1a_
  • Heterogens: ATP, 21O, DMS, MN, NA, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4aw1A (A:)
gamdgtaaeprpgagslqhaqpppqprkkrpedfkfgkilgegsfstvvlarelatsrey
aikilekrhiikenkvpyvtrerdvmsrldhpffvklyftfqddeklyfglsyakngell
kyirkigsfdetctrfytaeivsaleylhgkgiihrdlkpenillnedmhiqitdfgtak
vlspeskqaransfvgtaqyvspellteksackssdlwalgciiyqlvaglppfragneg
lifakiikleydfpekffpkardlvekllvldatkrlgceemegygplkahpffesvtwe
nlhqqtppklt

    Sequence, based on observed residues (ATOM records): (download) 
    >4aw1A (A:)
qhaqppprkkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyv
trerdvmsrldhpffvklyftfqddeklyfglsyakngellkyirkigsfdetctrfyta
eivsaleylhgkgiihrdlkpenillnedmhiqitdfgtakvlsaransfvgtaqyvspe
llteksackssdlwalgciiyqlvaglppfragneglifakiikleydfpekffpkardl
vekllvldatkrlgceemegygplkahpffesvtwenlhqqtppklt