PDB entry 4aq3

View 4aq3 on RCSB PDB site
Description: human bcl-2 with phenylacylsulfonamide inhibitor
Class: apoptosis
Keywords: apoptosis, chimera
Deposited on 2012-04-12, released 2012-06-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-11-21, with a file datestamp of 2012-11-16.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.203
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: apoptosis regulator bcl-2, bcl-2-like protein 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10415 (53-End)
      • variant (57)
      • variant (71)
    • Uniprot Q07817
    Domains in SCOPe 2.08: d4aq3a_
  • Chain 'B':
    Compound: apoptosis regulator bcl-2, bcl-2-like protein 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10415 (53-End)
      • variant (57)
      • variant (71)
    • Uniprot Q07817
    Domains in SCOPe 2.08: d4aq3b_
  • Chain 'C':
    Compound: apoptosis regulator bcl-2, bcl-2-like protein 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10415 (53-End)
      • variant (57)
      • variant (71)
    • Uniprot Q07817
    Domains in SCOPe 2.08: d4aq3c_
  • Chain 'D':
    Compound: apoptosis regulator bcl-2, bcl-2-like protein 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10415 (53-End)
      • variant (57)
      • variant (71)
    • Uniprot Q07817 (Start-52)
    Domains in SCOPe 2.08: d4aq3d_
  • Chain 'E':
    Compound: apoptosis regulator bcl-2, bcl-2-like protein 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10415 (53-End)
      • variant (57)
      • variant (71)
    • Uniprot Q07817
    Domains in SCOPe 2.08: d4aq3e_
  • Chain 'F':
    Compound: apoptosis regulator bcl-2, bcl-2-like protein 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10415 (53-End)
      • variant (57)
      • variant (71)
    • Uniprot Q07817 (Start-52)
    Domains in SCOPe 2.08: d4aq3f_
  • Heterogens: 398

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4aq3A (A:)
    gshmahagrtgydnreivmkyihyklsqrgyewdagddveenrteapegtesevvhlalr
    qagddfsrryrgdfaemssqlhltpftargrfatvveelfrdgvnwgrivaffefggvmc
    vesvnremsplvdnialwmteylnrhlhtwiqdnggwdafvelygpsmr
    

    Sequence, based on observed residues (ATOM records): (download)
    >4aq3A (A:)
    ydnreivmkyihyklsqrgyewdvvhlalrqagddfsrryrgdfaemssqlhltpftarg
    rfatvveelfrdgvnwgrivaffefggvmcvesvnremsplvdnialwmteylnrhlhtw
    iqdnggwdafvelyg
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4aq3B (B:)
    gshmahagrtgydnreivmkyihyklsqrgyewdagddveenrteapegtesevvhlalr
    qagddfsrryrgdfaemssqlhltpftargrfatvveelfrdgvnwgrivaffefggvmc
    vesvnremsplvdnialwmteylnrhlhtwiqdnggwdafvelygpsmr
    

    Sequence, based on observed residues (ATOM records): (download)
    >4aq3B (B:)
    ydnreivmkyihyklsqrgyewdvvhlalrqagddfsrryrgdfaemssqlhltpftarg
    rfatvveelfrdgvnwgrivaffefggvmcvesvnremsplvdnialwmteylnrhlhtw
    iqdnggwdafvelyg
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >4aq3C (C:)
    gshmahagrtgydnreivmkyihyklsqrgyewdagddveenrteapegtesevvhlalr
    qagddfsrryrgdfaemssqlhltpftargrfatvveelfrdgvnwgrivaffefggvmc
    vesvnremsplvdnialwmteylnrhlhtwiqdnggwdafvelygpsmr
    

    Sequence, based on observed residues (ATOM records): (download)
    >4aq3C (C:)
    ydnreivmkyihyklsqrgyewdvvhlalrqagddfsrryrgdfaemssqlhltpftarg
    rfatvveelfrdgvnwgrivaffefggvmcvesvnremsplvdnialwmteylnrhlhtw
    iqdnggwdafvelyg
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >4aq3D (D:)
    gshmahagrtgydnreivmkyihyklsqrgyewdagddveenrteapegtesevvhlalr
    qagddfsrryrgdfaemssqlhltpftargrfatvveelfrdgvnwgrivaffefggvmc
    vesvnremsplvdnialwmteylnrhlhtwiqdnggwdafvelygpsmr
    

    Sequence, based on observed residues (ATOM records): (download)
    >4aq3D (D:)
    ydnreivmkyihyklsqrgyewdsevvhlalrqagddfsrryrgdfaemssqlhltpfta
    rgrfatvveelfrdgvnwgrivaffefggvmcvesvnremsplvdnialwmteylnrhlh
    twiqdnggwdafvelyg
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >4aq3E (E:)
    gshmahagrtgydnreivmkyihyklsqrgyewdagddveenrteapegtesevvhlalr
    qagddfsrryrgdfaemssqlhltpftargrfatvveelfrdgvnwgrivaffefggvmc
    vesvnremsplvdnialwmteylnrhlhtwiqdnggwdafvelygpsmr
    

    Sequence, based on observed residues (ATOM records): (download)
    >4aq3E (E:)
    dnreivmkyihyklsqrgyewdavvhlalrqagddfsrryrgdfaemssqlhltpftarg
    rfatvveelfrdgvnwgrivaffefggvmcvesvnremsplvdnialwmteylnrhlhtw
    iqdnggwdafvelyg
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >4aq3F (F:)
    gshmahagrtgydnreivmkyihyklsqrgyewdagddveenrteapegtesevvhlalr
    qagddfsrryrgdfaemssqlhltpftargrfatvveelfrdgvnwgrivaffefggvmc
    vesvnremsplvdnialwmteylnrhlhtwiqdnggwdafvelygpsmr
    

    Sequence, based on observed residues (ATOM records): (download)
    >4aq3F (F:)
    ydnreivmkyihyklsqrgyewdaevvhlalrqagddfsrryrgdfaemssqlhltpfta
    rgrfatvveelfrdgvnwgrivaffefggvmcvesvnremsplvdnialwmteylnrhlh
    twiqdnggwdafvelyg