PDB entry 4anv

View 4anv on RCSB PDB site
Description: Complexes of PI3Kgamma with isoform selective inhibitors.
Class: transferase
Keywords: transferase
Deposited on 2012-03-22, released 2012-05-09
The last revision prior to the SCOPe 2.06 freeze date was dated 2012-06-27, with a file datestamp of 2012-06-22.
Experiment type: XRAY
Resolution: 2.13 Å
R-factor: 0.24312
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4anva1, d4anva2, d4anva3, d4anva4
  • Heterogens: SO4, 751, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4anvA (A:)
mllgsseesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyam
hpwvtskplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkksl
mdipesqseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldev
rkeewplvddctgvtgyheqltihgkdhesvftvslwdcdrkfrvkirgidipvlprntd
ltvfveaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiycgka
palsskasaespsseskgkvqllyyvnlllidhrfllrrgeyvlhmwqisgkgedqgsfn
adkltsatnpdkensmsisilldnychpialpkhqptpdpegdrvraempnqlrkqleai
iatdplnpltaedkellwhfryeslkhpkaypklfssvkwgqqeivaktyqllarrevwd
qsaldvgltmqlldcnfsdenvraiavqklesledddvlhyllqlvqavkfepyhdsala
rfllkrglrnkrighflfwflrseiaqsrhyqqrfavileaylrgcgtamlhdftqqvqv
iemlqkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrvpydpglkagalai
ekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrimesiwete
sldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkdevlnhwlkekspte
ekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfghilgnyksflgi
nkervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtg
mpeltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlvlgikqge
khsaefglvprgsghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4anvA (A:)
seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
skplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmeqdfvlrvcgr
deylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkeetvslwdcdrkfrvki
rgidipvlprnltvfveaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkga
llnlqiycqllyyvnlllidhrfllrrgeyvlhmwqisgfnadkltsatnpdkensmsis
illdnychpialpkhqraempnqlrkqleaiiatdplnpltaedkellwhfryeslkhpk
aypklfssvkwgqqeivaktyqllarrevwdqsaldvgltmqlldcnfsdenvraiavqk
lesledddvlhyllqlvqavkfepyhdsalarfllkrglrnkrighflfwflrseiaqsr
hyqqrfavileaylrgcgtamlhdftqqvqviemlqkvtldikslsaevssqvisqlkqk
lenlqnsqlpesfrvpydpglkagalaiekckvmaskkkplwlefkcadptalsnetigi
ifkhgddlrqdmlilqilrimesiwetesldlcllpygcistgdkigmieivkdattiak
iqqstvgntgafkdevlnhwlkekspteekfqaaverfvyscagycvatfvlgigdrhnd
nimitetgnlfhidfghikervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalr
hhtnlliilfsmmlmtgmpeltskedieyirdaltvgkneedakkyfldqievcrdkgwt
vqfnwflh