PDB entry 4anv

View 4anv on RCSB PDB site
Description: Complexes of PI3Kgamma with isoform selective inhibitors.
Class: transferase
Keywords: transferase
Deposited on 2012-03-22, released 2012-05-09
The last revision prior to the SCOPe 2.07 freeze date was dated 2012-06-27, with a file datestamp of 2012-06-22.
Experiment type: XRAY
Resolution: 2.13 Å
R-factor: 0.24312
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4anva1, d4anva2, d4anva3, d4anva4
  • Heterogens: SO4, 751, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4anvA (A:)
    mllgsseesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyam
    hpwvtskplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkksl
    mdipesqseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldev
    rkeewplvddctgvtgyheqltihgkdhesvftvslwdcdrkfrvkirgidipvlprntd
    ltvfveaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiycgka
    palsskasaespsseskgkvqllyyvnlllidhrfllrrgeyvlhmwqisgkgedqgsfn
    adkltsatnpdkensmsisilldnychpialpkhqptpdpegdrvraempnqlrkqleai
    iatdplnpltaedkellwhfryeslkhpkaypklfssvkwgqqeivaktyqllarrevwd
    qsaldvgltmqlldcnfsdenvraiavqklesledddvlhyllqlvqavkfepyhdsala
    rfllkrglrnkrighflfwflrseiaqsrhyqqrfavileaylrgcgtamlhdftqqvqv
    iemlqkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrvpydpglkagalai
    ekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrimesiwete
    sldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkdevlnhwlkekspte
    ekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfghilgnyksflgi
    nkervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtg
    mpeltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlvlgikqge
    khsaefglvprgsghhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >4anvA (A:)
    seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
    skplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmeqdfvlrvcgr
    deylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkeetvslwdcdrkfrvki
    rgidipvlprnltvfveaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkga
    llnlqiycqllyyvnlllidhrfllrrgeyvlhmwqisgfnadkltsatnpdkensmsis
    illdnychpialpkhqraempnqlrkqleaiiatdplnpltaedkellwhfryeslkhpk
    aypklfssvkwgqqeivaktyqllarrevwdqsaldvgltmqlldcnfsdenvraiavqk
    lesledddvlhyllqlvqavkfepyhdsalarfllkrglrnkrighflfwflrseiaqsr
    hyqqrfavileaylrgcgtamlhdftqqvqviemlqkvtldikslsaevssqvisqlkqk
    lenlqnsqlpesfrvpydpglkagalaiekckvmaskkkplwlefkcadptalsnetigi
    ifkhgddlrqdmlilqilrimesiwetesldlcllpygcistgdkigmieivkdattiak
    iqqstvgntgafkdevlnhwlkekspteekfqaaverfvyscagycvatfvlgigdrhnd
    nimitetgnlfhidfghikervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalr
    hhtnlliilfsmmlmtgmpeltskedieyirdaltvgkneedakkyfldqievcrdkgwt
    vqfnwflh