PDB entry 4akn

View 4akn on RCSB PDB site
Description: N-Terminal Bromodomain of Human BRD2 With tbutyl-phenyl-amino- dimethyl-oxazolyl-quinoline-carboxylic acid
Class: protein binding
Keywords: protein binding, inhibitor, histone, epigenetic reader
Deposited on 2012-02-26, released 2012-07-04
The last revision prior to the SCOPe 2.05 freeze date was dated 2012-11-14, with a file datestamp of 2012-11-09.
Experiment type: XRAY
Resolution: 1.82 Å
R-factor: 0.1695
AEROSPACI score: 0.54 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bromodomain-containing protein 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4akna_
  • Chain 'B':
    Compound: Bromodomain-containing protein 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4aknb_
  • Chain 'C':
    Compound: Bromodomain-containing protein 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4aknc_
  • Heterogens: EDO, S5B, SO4, DMS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4aknA (A:)
gsshhhhhhssglvprgshmsnpkkpgrvtnqlqylhkvvmkalwkhqfawpfrqpvdav
klglpdyhkiikqpmdmgtikrrlennyywaasecmqdfntmftncyiynkptddivlma
qtlekiflqkvasmpqeeqelvvtipnshkkga

    Sequence, based on observed residues (ATOM records): (download) 
    >4aknA (A:)
vtnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlenny
ywaasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpqeeqe

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4aknB (B:)
gsshhhhhhssglvprgshmsnpkkpgrvtnqlqylhkvvmkalwkhqfawpfrqpvdav
klglpdyhkiikqpmdmgtikrrlennyywaasecmqdfntmftncyiynkptddivlma
qtlekiflqkvasmpqeeqelvvtipnshkkga

    Sequence, based on observed residues (ATOM records): (download) 
    >4aknB (B:)
grvtnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlen
nyywaasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpqe

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4aknC (C:)
gsshhhhhhssglvprgshmsnpkkpgrvtnqlqylhkvvmkalwkhqfawpfrqpvdav
klglpdyhkiikqpmdmgtikrrlennyywaasecmqdfntmftncyiynkptddivlma
qtlekiflqkvasmpqeeqelvvtipnshkkga

    Sequence, based on observed residues (ATOM records): (download) 
    >4aknC (C:)
tnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlennyy
waasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpq