PDB entry 4a9l

View 4a9l on RCSB PDB site
Description: n-terminal bromodomain of human brd4 with 1,3-dimethyl-6-(morpholine- 4-sulfonyl)-1,2,3,4-tetrahydroquinazolin-2-one
Class: signaling protein
Keywords: inhibitor, histone, epigenetic reader, signaling protein
Deposited on 2011-11-26, released 2012-01-11
The last revision prior to the SCOPe 2.07 freeze date was dated 2012-02-08, with a file datestamp of 2012-02-03.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: 0.17931
AEROSPACI score: 0.6 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bromodomain-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60885 (2-End)
      • expression tag (0-1)
    Domains in SCOPe 2.07: d4a9la1, d4a9la2
  • Heterogens: EDO, P9L, NO3, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4a9lA (A:)
smnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
nelptee

    Sequence, based on observed residues (ATOM records): (download) 
    >4a9lA (A:)
smnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
nelpte