PDB entry 4a9i

View 4a9i on RCSB PDB site
Description: N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 3-methyl-1,2,3,4- tetrahydroquinazolin-2-one
Class: signaling protein
Keywords: inhibitor, histone, epigenetic reader, signaling protein
Deposited on 2011-11-26, released 2012-01-11
The last revision prior to the SCOPe 2.05 freeze date was dated 2012-02-08, with a file datestamp of 2012-02-03.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: 0.19743
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: bromodomain containing 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4a9ia_
  • Chain 'B':
    Compound: bromodomain containing 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P25440
      • expression tag (13)
    Domains in SCOPe 2.05: d4a9ib_
  • Chain 'C':
    Compound: bromodomain containing 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4a9ic_
  • Heterogens: P9I, SO4, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4a9iA (A:)
gsshhhhhhssglvprgshmsnpkkpgrvtnqlqylhkvvmkalwkhqfawpfrqpvdav
klglpdyhkiikqpmdmgtikrrlennyywaasecmqdfntmftncyiynkptddivlma
qtlekiflqkvasmpqeeqelvvtipknshkkga

    Sequence, based on observed residues (ATOM records): (download) 
    >4a9iA (A:)
vtnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlenny
ywaasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpqee

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4a9iB (B:)
gsshhhhhhssglvprgshmsnpkkpgrvtnqlqylhkvvmkalwkhqfawpfrqpvdav
klglpdyhkiikqpmdmgtikrrlennyywaasecmqdfntmftncyiynkptddivlma
qtlekiflqkvasmpqeeqelvvtipknshkkga

    Sequence, based on observed residues (ATOM records): (download) 
    >4a9iB (B:)
vpgrvtnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrl
ennyywaasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpqeeqe

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4a9iC (C:)
gsshhhhhhssglvprgshmsnpkkpgrvtnqlqylhkvvmkalwkhqfawpfrqpvdav
klglpdyhkiikqpmdmgtikrrlennyywaasecmqdfntmftncyiynkptddivlma
qtlekiflqkvasmpqeeqelvvtipknshkkga

    Sequence, based on observed residues (ATOM records): (download) 
    >4a9iC (C:)
tnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlennyy
waasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpq