PDB entry 4a2u

View 4a2u on RCSB PDB site
Description: CRP(CAP) from Myco. Tuberculosis, with cAMP
Class: transcription
Keywords: transcription, cyclic amp receptor, transcription regulation, catabolite gene activator protein, allostery, DNA-binding
Deposited on 2011-09-28, released 2012-10-10
The last revision prior to the SCOPe 2.04 freeze date was dated 2012-10-10, with a file datestamp of 2012-10-05.
Experiment type: XRAY
Resolution: 2.63 Å
R-factor: 0.18853
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: probable transcriptional regulatory protein (probably crp/ fnr-family)
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4a2ua1, d4a2ua2
  • Chain 'B':
    Compound: probable transcriptional regulatory protein (probably crp/ fnr-family)
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4a2ub1, d4a2ub2
  • Chain 'C':
    Compound: probable transcriptional regulatory protein (probably crp/ fnr-family)
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4a2uc1, d4a2uc2
  • Chain 'D':
    Compound: probable transcriptional regulatory protein (probably crp/ fnr-family)
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4a2ud1, d4a2ud2
  • Chain 'E':
    Compound: probable transcriptional regulatory protein (probably crp/ fnr-family)
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4a2ue1, d4a2ue2
  • Chain 'F':
    Compound: probable transcriptional regulatory protein (probably crp/ fnr-family)
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O69644 (3-226)
      • expression tag (1)
    Domains in SCOPe 2.04: d4a2uf1, d4a2uf2
  • Chain 'G':
    Compound: probable transcriptional regulatory protein (probably crp/ fnr-family)
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4a2ug1, d4a2ug2
  • Chain 'H':
    Compound: probable transcriptional regulatory protein (probably crp/ fnr-family)
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O69644 (3-226)
      • expression tag (0-2)
    Domains in SCOPe 2.04: d4a2uh1, d4a2uh2
  • Heterogens: CMP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4a2uA (A:)
gshmdeilaragifqgvepsaiaaltkqlqpvdfprghtvfaegepgdrlyiiisgkvki
grrapdgrenlltimgpsdmfgelsifdpgprtssattitevravsmdrdalrswiadrp
eiseqllrvlarrlrrtnnnladliftdvpgrvakqllqlaqrfgtqeggalrvthdltq
eeiaqlvgasretvnkaladfahrgwirlegksvlisdserlarrar

    Sequence, based on observed residues (ATOM records): (download) 
    >4a2uA (A:)
mdeilaragifqgvepsaiaaltkqlqpvdfprghtvfaegepgdrlyiiisgkvkigrr
apdgrenlltimgpsdmfgelsifdpgprtssattitevravsmdrdalrswiadrpeis
eqllrvlarrlrrtnnnladliftdvpgrvakqllqlaqrfgtqeggalrvthdltqeei
aqlvgasretvnkaladfahrgwirlegksvlisdserlarrar

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4a2uB (B:)
gshmdeilaragifqgvepsaiaaltkqlqpvdfprghtvfaegepgdrlyiiisgkvki
grrapdgrenlltimgpsdmfgelsifdpgprtssattitevravsmdrdalrswiadrp
eiseqllrvlarrlrrtnnnladliftdvpgrvakqllqlaqrfgtqeggalrvthdltq
eeiaqlvgasretvnkaladfahrgwirlegksvlisdserlarrar

    Sequence, based on observed residues (ATOM records): (download) 
    >4a2uB (B:)
mdeilaragifqgvepsaiaaltkqlqpvdfprghtvfaegepgdrlyiiisgkvkigrr
apdgrenlltimgpsdmfgelsifdpgprtssattitevravsmdrdalrswiadrpeis
eqllrvlarrlrrtnnnladliftdvpgrvakqllqlaqrfgtqeggalrvthdltqeei
aqlvgasretvnkaladfahrgwirlegksvlisdserlarrar

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4a2uC (C:)
gshmdeilaragifqgvepsaiaaltkqlqpvdfprghtvfaegepgdrlyiiisgkvki
grrapdgrenlltimgpsdmfgelsifdpgprtssattitevravsmdrdalrswiadrp
eiseqllrvlarrlrrtnnnladliftdvpgrvakqllqlaqrfgtqeggalrvthdltq
eeiaqlvgasretvnkaladfahrgwirlegksvlisdserlarrar

    Sequence, based on observed residues (ATOM records): (download) 
    >4a2uC (C:)
mdeilaragifqgvepsaiaaltkqlqpvdfprghtvfaegepgdrlyiiisgkvkigrr
apdgrenlltimgpsdmfgelsifdpgprtssattitevravsmdrdalrswiadrpeis
eqllrvlarrlrrtnnnladliftdvpgrvakqllqlaqrfgtqeggalrvthdltqeei
aqlvgasretvnkaladfahrgwirlegksvlisdserlarrar

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4a2uD (D:)
gshmdeilaragifqgvepsaiaaltkqlqpvdfprghtvfaegepgdrlyiiisgkvki
grrapdgrenlltimgpsdmfgelsifdpgprtssattitevravsmdrdalrswiadrp
eiseqllrvlarrlrrtnnnladliftdvpgrvakqllqlaqrfgtqeggalrvthdltq
eeiaqlvgasretvnkaladfahrgwirlegksvlisdserlarrar

    Sequence, based on observed residues (ATOM records): (download) 
    >4a2uD (D:)
saiaaltkqlqpvdfprghtvfaegepgdrlyiiisgkvkigrrapdgrenlltimgpsd
mfgelsifdpgprtssattitevravsmdrdalrswiadrpeiseqllrvlarrlrrtnn
nladliftdvpgrvakqllqlaqrfgtqeggalrvthdltqeeiaqlvgasretvnkala
dfahrgwirlegksvlisdserlarrar

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4a2uE (E:)
gshmdeilaragifqgvepsaiaaltkqlqpvdfprghtvfaegepgdrlyiiisgkvki
grrapdgrenlltimgpsdmfgelsifdpgprtssattitevravsmdrdalrswiadrp
eiseqllrvlarrlrrtnnnladliftdvpgrvakqllqlaqrfgtqeggalrvthdltq
eeiaqlvgasretvnkaladfahrgwirlegksvlisdserlarrar

    Sequence, based on observed residues (ATOM records): (download) 
    >4a2uE (E:)
mdeilaragifqgvepsaiaaltkqlqpvdfprghtvfaegepgdrlyiiisgkvkigrr
apdgrenlltimgpsdmfgelsifdpgprtssattitevravsmdrdalrswiadrpeis
eqllrvlarrlrrtnnnladliftdvpgrvakqllqlaqrfgtqeggalrvthdltqeei
aqlvgasretvnkaladfahrgwirlegksvlisdserlarrar

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4a2uF (F:)
gshmdeilaragifqgvepsaiaaltkqlqpvdfprghtvfaegepgdrlyiiisgkvki
grrapdgrenlltimgpsdmfgelsifdpgprtssattitevravsmdrdalrswiadrp
eiseqllrvlarrlrrtnnnladliftdvpgrvakqllqlaqrfgtqeggalrvthdltq
eeiaqlvgasretvnkaladfahrgwirlegksvlisdserlarrar

    Sequence, based on observed residues (ATOM records): (download) 
    >4a2uF (F:)
smdeilaragifqgvepsaiaaltkqlqpvdfprghtvfaegepgdrlyiiisgkvkigr
rapdgrenlltimgpsdmfgelsifdpgprtssattitevravsmdrdalrswiadrpei
seqllrvlarrlrrtnnnladliftdvpgrvakqllqlaqrfgtqeggalrvthdltqee
iaqlvgasretvnkaladfahrgwirlegksvlisdserlarrar

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >4a2uG (G:)
gshmdeilaragifqgvepsaiaaltkqlqpvdfprghtvfaegepgdrlyiiisgkvki
grrapdgrenlltimgpsdmfgelsifdpgprtssattitevravsmdrdalrswiadrp
eiseqllrvlarrlrrtnnnladliftdvpgrvakqllqlaqrfgtqeggalrvthdltq
eeiaqlvgasretvnkaladfahrgwirlegksvlisdserlarrar

    Sequence, based on observed residues (ATOM records): (download) 
    >4a2uG (G:)
mdeilaragifqgvepsaiaaltkqlqpvdfprghtvfaegepgdrlyiiisgkvkigrr
apdgrenlltimgpsdmfgelsifdpgprtssattitevravsmdrdalrswiadrpeis
eqllrvlarrlrrtnnnladliftdvpgrvakqllqlaqrfgtqeggalrvthdltqeei
aqlvgasretvnkaladfahrgwirlegksvlisdserlarrar

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4a2uH (H:)
gshmdeilaragifqgvepsaiaaltkqlqpvdfprghtvfaegepgdrlyiiisgkvki
grrapdgrenlltimgpsdmfgelsifdpgprtssattitevravsmdrdalrswiadrp
eiseqllrvlarrlrrtnnnladliftdvpgrvakqllqlaqrfgtqeggalrvthdltq
eeiaqlvgasretvnkaladfahrgwirlegksvlisdserlarrar