PDB entry 3x2q

View 3x2q on RCSB PDB site
Description: X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution
Class: oxidoreductase
Keywords: oxidoreductase, respiratory chain, electron transport, heme, iron, mitochondorial inner membrane
Deposited on 2014-12-26, released 2015-06-10
The last revision prior to the SCOPe 2.06 freeze date was dated 2015-06-10, with a file datestamp of 2015-06-05.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cytochrome c oxidase subunit 1
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3x2qa_
  • Chain 'B':
    Compound: Cytochrome c oxidase subunit 2
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3x2qb1, d3x2qb2
  • Chain 'C':
    Compound: Cytochrome c oxidase subunit 3
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3x2qc_
  • Chain 'D':
    Compound: cytochrome c oxidase subunit 4 isoform 1, mitochondrial
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3x2qd_
  • Chain 'E':
    Compound: cytochrome c oxidase subunit 5a, mitochondrial
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3x2qe_
  • Chain 'F':
    Compound: cytochrome c oxidase subunit 5b, mitochondrial
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3x2qf_
  • Chain 'G':
    Compound: Cytochrome c oxidase subunit 6A2, mitochondrial
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3x2qg_
  • Chain 'H':
    Compound: Cytochrome c oxidase subunit 6B1
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3x2qh_
  • Chain 'I':
    Compound: Cytochrome c oxidase subunit 6C
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3x2qi_
  • Chain 'J':
    Compound: cytochrome c oxidase subunit 7a1, mitochondrial
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3x2qj_
  • Chain 'K':
    Compound: cytochrome c oxidase subunit 7b, mitochondrial
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3x2qk_
  • Chain 'L':
    Compound: cytochrome c oxidase subunit 7c, mitochondrial
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3x2ql_
  • Chain 'M':
    Compound: cytochrome c oxidase subunit 8b, mitochondrial
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3x2qm_
  • Chain 'N':
    Compound: Cytochrome c oxidase subunit 1
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3x2qn_
  • Chain 'O':
    Compound: Cytochrome c oxidase subunit 2
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3x2qo1, d3x2qo2
  • Chain 'P':
    Compound: Cytochrome c oxidase subunit 3
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3x2qp_
  • Chain 'Q':
    Compound: cytochrome c oxidase subunit 4 isoform 1, mitochondrial
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3x2qq_
  • Chain 'R':
    Compound: cytochrome c oxidase subunit 5a, mitochondrial
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3x2qr_
  • Chain 'S':
    Compound: cytochrome c oxidase subunit 5b, mitochondrial
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3x2qs_
  • Chain 'T':
    Compound: Cytochrome c oxidase subunit 6A2, mitochondrial
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3x2qt_
  • Chain 'U':
    Compound: Cytochrome c oxidase subunit 6B1
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3x2qu_
  • Chain 'V':
    Compound: Cytochrome c oxidase subunit 6C
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3x2qv_
  • Chain 'W':
    Compound: cytochrome c oxidase subunit 7a1, mitochondrial
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3x2qw_
  • Chain 'X':
    Compound: cytochrome c oxidase subunit 7b, mitochondrial
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3x2qx_
  • Chain 'Y':
    Compound: cytochrome c oxidase subunit 7c, mitochondrial
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3x2qy_
  • Chain 'Z':
    Compound: cytochrome c oxidase subunit 8b, mitochondrial
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3x2qz_
  • Heterogens: CYN, HEA, CU, MG, NA, TGL, PGV, CUA, CHD, UNX, CDL, PEK, PSC, ZN, DMU, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3x2qA (A:)
mfinrwlfstnhkdigtlyllfgawagmvgtalslliraelgqpgtllgddqiynvvvta
hafvmiffmvmpimiggfgnwlvplmigapdmafprmnnmsfwllppsfllllassmvea
gagtgwtvypplagnlahagasvdltifslhlagvssilgainfittiinmkppamsqyq
tplfvwsvmitavllllslpvlaagitmlltdrnlnttffdpagggdpilyqhlfwffgh
pevyililpgfgmishivtyysgkkepfgymgmvwammsigflgfivwahhmftvgmdvd
trayftsatmiiaiptgvkvfswlatlhggnikwspammwalgfiflftvggltgivlan
ssldivlhdtyyvvahfhyvlsmgavfaimggfvhwfplfsgytlndtwakihfaimfvg
vnmtffpqhflglsgmprrysdypdaytmwntissmgsfisltavmlmvfiiweafaskr
evltvdltttnlewlngcpppyhtfeeptyvnlk

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3x2qB (B:)
maypmqlgfqdatspimeellhfhdhtlmivflisslvlyiislmlttklthtstmdaqe
vetiwtilpaiililialpslrilymmdeinnpsltvktmghqwywsyeytdyedlsfds
ymiptselkpgelrllevdnrvvlpmemtirmlvssedvlhswavpslglktdaipgrln
qttlmssrpglyygqcseicgsnhsfmpivlelvplkyfekwsasml

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3x2qC (C:)
mthqthayhmvnpspwpltgalsallmtsgltmwfhfnsmtllmiglttnmltmyqwwrd
virestfqghhtpavqkglrygmilfiisevlfftgffwafyhsslaptpelggcwpptg
ihplnplevpllntsvllasgvsitwahhslmegdrkhmlqalfititlgvyftllqase
yyeapftisdgvygstffvatgfhglhviigstflivcffrqlkfhftsnhhfgfeaaaw
ywhfvdvvwlflyvsiywwgs

    Sequence, based on observed residues (ATOM records): (download) 
    >3x2qC (C:)
hqthayhmvnpspwpltgalsallmtsgltmwfhfnsmtllmiglttnmltmyqwwrdvi
restfqghhtpavqkglrygmilfiisevlfftgffwafyhsslaptpelggcwpptgih
plnplevpllntsvllasgvsitwahhslmegdrkhmlqalfititlgvyftllqaseyy
eapftisdgvygstffvatgfhglhviigstflivcffrqlkfhftsnhhfgfeaaawyw
hfvdvvwlflyvsiywwgs

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3x2qD (D:)
ahgsvvksedyalpsyvdrrdyplpdvahvknlsasqkalkekekaswsslsidekvely
rlkfkesfaemnrstnewktvvgaamffigftallliwekhyvygpiphtfeeewvakqt
krmldmkvapiqgfsakwdydknewkk

    Sequence, based on observed residues (ATOM records): (download) 
    >3x2qD (D:)
svvksedyalpsyvdrrdyplpdvahvknlsasqkalkekekaswsslsidekvelyrlk
fkesfaemnrstnewktvvgaamffigftallliwekhyvygpiphtfeeewvakqtkrm
ldmkvapiqgfsakwdydknewkk

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >3x2qE (E:)
shgshetdeefdarwvtyfnkpdidawelrkgmntlvgydlvpepkiidaalracrrlnd
fasavrilevvkdkagphkeiypyviqelrptlnelgistpeelgldkv

    Sequence, based on observed residues (ATOM records): (download) 
    >3x2qE (E:)
hetdeefdarwvtyfnkpdidawelrkgmntlvgydlvpepkiidaalracrrlndfasa
vrilevvkdkagphkeiypyviqelrptlnelgistpeelgldkv

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3x2qF (F:)
asgggvptdeeqatglerevmlaarkgqdpynilapkatsgtkedpnlvpsitnkrivgc
iceednstviwfwlhkgeaqrcpscgthyklvphqlah

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >3x2qG (G:)
asaakgdhggtgartwrfltfglalpsvalctlnswlhsghrerpafipyhhlrirtkpf
swgdgnhtffhnprvnplptgyekp

    Sequence, based on observed residues (ATOM records): (download) 
    >3x2qG (G:)
asaakgdhggtgartwrfltfglalpsvalctlnswlhsghrerpafipyhhlrirtkpf
swgdgnhtffhnprvnplptgyek

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >3x2qH (H:)
aediqakiknyqtapfdsrfpnqnqtrncwqnyldfhrcekamtakggdvsvcewyrrvy
kslcpiswvstwddrraegtfpgki

    Sequence, based on observed residues (ATOM records): (download) 
    >3x2qH (H:)
kiknyqtapfdsrfpnqnqtrncwqnyldfhrcekamtakggdvsvcewyrrvykslcpi
swvstwddrraegtfpgki

  • Chain 'I':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3x2qI (I:)
stalakpqmrgllarrlrfhivgafmvslgfatfykfavaekrkkayadfyrnydsmkdf
eemrkagifqsak

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >3x2qJ (J:)
fenrvaekqklfqednglpvhlkggatdnilyrvtmtlclggtlyslyclgwasfphkk

    Sequence, based on observed residues (ATOM records): (download) 
    >3x2qJ (J:)
fenrvaekqklfqednglpvhlkggatdnilyrvtmtlclggtlyslyclgwasfphk

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >3x2qK (K:)
ihqkrapdfhdkygnavlasgatfcvavwvymatqigiewnpspvgrvtpkewreq

    Sequence, based on observed residues (ATOM records): (download) 
    >3x2qK (K:)
apdfhdkygnavlasgatfcvavwvymatqigiewnpspvgrvtpkewr

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >3x2qL (L:)
shyeegpgknipfsvenkwrllammtlffgsgfaapffivrhqllkk

    Sequence, based on observed residues (ATOM records): (download) 
    >3x2qL (L:)
hyeegpgknipfsvenkwrllammtlffgsgfaapffivrhqllkk

  • Chain 'M':
    Sequence, based on SEQRES records: (download) 
    >3x2qM (M:)
itakpaktptspkeqaiglsvtflsfllpagwvlyhldnykkssaa

    Sequence, based on observed residues (ATOM records): (download) 
    >3x2qM (M:)
itakpaktptspkeqaiglsvtflsfllpagwvlyhldnykks

  • Chain 'N':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3x2qN (N:)
mfinrwlfstnhkdigtlyllfgawagmvgtalslliraelgqpgtllgddqiynvvvta
hafvmiffmvmpimiggfgnwlvplmigapdmafprmnnmsfwllppsfllllassmvea
gagtgwtvypplagnlahagasvdltifslhlagvssilgainfittiinmkppamsqyq
tplfvwsvmitavllllslpvlaagitmlltdrnlnttffdpagggdpilyqhlfwffgh
pevyililpgfgmishivtyysgkkepfgymgmvwammsigflgfivwahhmftvgmdvd
trayftsatmiiaiptgvkvfswlatlhggnikwspammwalgfiflftvggltgivlan
ssldivlhdtyyvvahfhyvlsmgavfaimggfvhwfplfsgytlndtwakihfaimfvg
vnmtffpqhflglsgmprrysdypdaytmwntissmgsfisltavmlmvfiiweafaskr
evltvdltttnlewlngcpppyhtfeeptyvnlk

  • Chain 'O':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3x2qO (O:)
maypmqlgfqdatspimeellhfhdhtlmivflisslvlyiislmlttklthtstmdaqe
vetiwtilpaiililialpslrilymmdeinnpsltvktmghqwywsyeytdyedlsfds
ymiptselkpgelrllevdnrvvlpmemtirmlvssedvlhswavpslglktdaipgrln
qttlmssrpglyygqcseicgsnhsfmpivlelvplkyfekwsasml

  • Chain 'P':
    Sequence, based on SEQRES records: (download) 
    >3x2qP (P:)
mthqthayhmvnpspwpltgalsallmtsgltmwfhfnsmtllmiglttnmltmyqwwrd
virestfqghhtpavqkglrygmilfiisevlfftgffwafyhsslaptpelggcwpptg
ihplnplevpllntsvllasgvsitwahhslmegdrkhmlqalfititlgvyftllqase
yyeapftisdgvygstffvatgfhglhviigstflivcffrqlkfhftsnhhfgfeaaaw
ywhfvdvvwlflyvsiywwgs

    Sequence, based on observed residues (ATOM records): (download) 
    >3x2qP (P:)
hqthayhmvnpspwpltgalsallmtsgltmwfhfnsmtllmiglttnmltmyqwwrdvi
restfqghhtpavqkglrygmilfiisevlfftgffwafyhsslaptpelggcwpptgih
plnplevpllntsvllasgvsitwahhslmegdrkhmlqalfititlgvyftllqaseyy
eapftisdgvygstffvatgfhglhviigstflivcffrqlkfhftsnhhfgfeaaawyw
hfvdvvwlflyvsiywwgs

  • Chain 'Q':
    Sequence, based on SEQRES records: (download) 
    >3x2qQ (Q:)
ahgsvvksedyalpsyvdrrdyplpdvahvknlsasqkalkekekaswsslsidekvely
rlkfkesfaemnrstnewktvvgaamffigftallliwekhyvygpiphtfeeewvakqt
krmldmkvapiqgfsakwdydknewkk

    Sequence, based on observed residues (ATOM records): (download) 
    >3x2qQ (Q:)
svvksedyalpsyvdrrdyplpdvahvknlsasqkalkekekaswsslsidekvelyrlk
fkesfaemnrstnewktvvgaamffigftallliwekhyvygpiphtfeeewvakqtkrm
ldmkvapiqgfsakwdydknewkk

  • Chain 'R':
    Sequence, based on SEQRES records: (download) 
    >3x2qR (R:)
shgshetdeefdarwvtyfnkpdidawelrkgmntlvgydlvpepkiidaalracrrlnd
fasavrilevvkdkagphkeiypyviqelrptlnelgistpeelgldkv

    Sequence, based on observed residues (ATOM records): (download) 
    >3x2qR (R:)
hetdeefdarwvtyfnkpdidawelrkgmntlvgydlvpepkiidaalracrrlndfasa
vrilevvkdkagphkeiypyviqelrptlnelgistpeelgldkv

  • Chain 'S':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3x2qS (S:)
asgggvptdeeqatglerevmlaarkgqdpynilapkatsgtkedpnlvpsitnkrivgc
iceednstviwfwlhkgeaqrcpscgthyklvphqlah

  • Chain 'T':
    Sequence, based on SEQRES records: (download) 
    >3x2qT (T:)
asaakgdhggtgartwrfltfglalpsvalctlnswlhsghrerpafipyhhlrirtkpf
swgdgnhtffhnprvnplptgyekp

    Sequence, based on observed residues (ATOM records): (download) 
    >3x2qT (T:)
asaakgdhggtgartwrfltfglalpsvalctlnswlhsghrerpafipyhhlrirtkpf
swgdgnhtffhnprvnplptgyek

  • Chain 'U':
    Sequence, based on SEQRES records: (download) 
    >3x2qU (U:)
aediqakiknyqtapfdsrfpnqnqtrncwqnyldfhrcekamtakggdvsvcewyrrvy
kslcpiswvstwddrraegtfpgki

    Sequence, based on observed residues (ATOM records): (download) 
    >3x2qU (U:)
kiknyqtapfdsrfpnqnqtrncwqnyldfhrcekamtakggdvsvcewyrrvykslcpi
swvstwddrraegtfpgki

  • Chain 'V':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3x2qV (V:)
stalakpqmrgllarrlrfhivgafmvslgfatfykfavaekrkkayadfyrnydsmkdf
eemrkagifqsak

  • Chain 'W':
    Sequence, based on SEQRES records: (download) 
    >3x2qW (W:)
fenrvaekqklfqednglpvhlkggatdnilyrvtmtlclggtlyslyclgwasfphkk

    Sequence, based on observed residues (ATOM records): (download) 
    >3x2qW (W:)
fenrvaekqklfqednglpvhlkggatdnilyrvtmtlclggtlyslyclgwasfphk

  • Chain 'X':
    Sequence, based on SEQRES records: (download) 
    >3x2qX (X:)
ihqkrapdfhdkygnavlasgatfcvavwvymatqigiewnpspvgrvtpkewreq

    Sequence, based on observed residues (ATOM records): (download) 
    >3x2qX (X:)
apdfhdkygnavlasgatfcvavwvymatqigiewnpspvgrvtpkewr

  • Chain 'Y':
    Sequence, based on SEQRES records: (download) 
    >3x2qY (Y:)
shyeegpgknipfsvenkwrllammtlffgsgfaapffivrhqllkk

    Sequence, based on observed residues (ATOM records): (download) 
    >3x2qY (Y:)
hyeegpgknipfsvenkwrllammtlffgsgfaapffivrhqllkk

  • Chain 'Z':
    Sequence, based on SEQRES records: (download) 
    >3x2qZ (Z:)
itakpaktptspkeqaiglsvtflsfllpagwvlyhldnykkssaa

    Sequence, based on observed residues (ATOM records): (download) 
    >3x2qZ (Z:)
itakpaktptspkeqaiglsvtflsfllpagwvlyhldnykks