PDB entry 3wff

View 3wff on RCSB PDB site
Description: Mineralocorticoid receptor ligand-binding domain with compuond 2b
Class: transcription/inhibitor
Keywords: NUCLEAR RECEPTOR, TRANSCRIPTION FACTOR, TRANSCRIPTION, HYPERTENSION, NON-STEROIDAL ANTAGONIST, ACTIVATING MUTATION, TRANSCRIPTION-INHIBITOR complex
Deposited on 2013-07-19, released 2013-08-21
The last revision prior to the SCOPe 2.05 freeze date was dated 2013-08-21, with a file datestamp of 2013-08-16.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: 0.188
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mineralocorticoid receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: NR3C2, MCR, MLR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08235 (Start-274)
      • engineered mutation (98)
      • engineered mutation (100)
      • engineered mutation (266)
    Domains in SCOPe 2.05: d3wffa_
  • Heterogens: WFF, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3wffA (A:)
gsapakepsvntalvpqlstisraltpspvmvleniepeivyagydsskpdtaenllstl
nrlagkqmiqvvkwakvlpgfknlpledqitliqyswmsllsfalswrsykhtnsqflyf
apdlvfneekmhqsamyelcqgmhqislqfvrlqltfeeytimkvllllstipkdglksq
aafeemrtnyikelrkmvtkcpnnsgqswqrfyqltklldsmhdlvsdllefcfytfres
halkvefpamlveiisdqlpkvesgnvkplyfhrk

    Sequence, based on observed residues (ATOM records): (download) 
    >3wffA (A:)
lstisraltpspvmvleniepeivyagydsskpdtaenllstlnrlagkqmiqvvkwakv
lpgfknlpledqitliqyswmsllsfalswrsykhtnsqflyfapdlvfneekmhqsamy
elcqgmhqislqfvrlqltfeeytimkvllllstipkdglksqaafeemrtnyikelrkm
vtkcpnnsgqswqrfyqltklldsmhdlvsdllefcfytfreshalkvefpamlveiisd
qlpkvesgnvkplyfhrk