PDB entry 3wbl

View 3wbl on RCSB PDB site
Description: Crystal structure of CDK2 in complex with pyrazolopyrimidine inhibitor
Class: transferase/transferase inhibitor
Keywords: Binding Sites, Tumor, Cyclin-Dependent Kinase 2, Drug Design, MAP Kinase Kinase 2, MK2, Protein Kinase Inhibitors, Pyrazoles, Pyrimidines, Structure-Activity Relationship, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2013-05-20, released 2013-10-30
The last revision prior to the SCOPe 2.07 freeze date was dated 2013-10-30, with a file datestamp of 2013-10-25.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.192
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cyclin-dependent kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CDK2, CDKN2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3wbla_
  • Heterogens: ACT, PDY, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3wblA (A:)
    menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
    pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
    hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
    stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
    pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl
    

    Sequence, based on observed residues (ATOM records): (download)
    >3wblA (A:)
    menfqkvekigegtygvvykarnktgevvalkkirlgvpstaireisllkelnhpnivkl
    ldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshrvlhr
    dlkpqnllintegaikladfglarafgvvtlwyrapeillgckyystavdiwslgcifae
    mvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpkwarqdfskvvppl
    dedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl