PDB entry 3w10
View 3w10 on RCSB PDB site
Description: Aurora kinase A complexed to pyrazole aminoquinoline I
Class: transferase/transferase inhibitor
Keywords: kinase, pyrazole aminoquinoline, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on
2012-11-06, released
2014-02-05
The last revision prior to the SCOPe 2.05 freeze date was dated
2014-02-05, with a file datestamp of
2014-01-31.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.249
AEROSPACI score: 0.17
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Aurora kinase A
Species: Homo sapiens [TaxId:9606]
Gene: AURKA, AIK, AIRK1, ARK1, AURA, AYK1, BTAK, IAK1, STK15, STK6
Database cross-references and differences (RAF-indexed):
- Uniprot O14965 (0-End)
- engineered mutation (161-162)
Domains in SCOPe 2.05: d3w10a_ - Heterogens: RO9, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3w10A (A:)
rqwaledfeigrplgkgkfgnvylarekqskfilalkvlfkaqlekagvehqlrreveiq
shlrhpnilrlygyfhdatrvylileyaplgtvyrelqklskfdeqrtatyitelanals
ychskrvihrdikpenlllgsagelkiadfgwsvhapssrraalcgtldylppemiegrm
hdekvdlwslgvlcyeflvgkppfeantyqetykrisrveftfpdfvtegardlisrllk
hnpsqrpmlrevlehpwitansskpsncqnkesaskqs
Sequence, based on observed residues (ATOM records): (download)
>3w10A (A:)
rqwaledfeigrplgkgkfgnvylarekqskfilalkvlfkaqlekagvehqlrreveiq
shlrhpnilrlygyfhdatrvylileyaplgtvyrelqklskfdeqrtatyitelanals
ychskrvihrdikpenlllgsagelkiadfgwsvhapssrraalcgtldylppemiegrm
hdekvdlwslgvlcyeflvgkppfeantyqetykrisrveftfpdfvtegardlisrllk
hnpsqrpmlrevlehpwitanss