PDB entry 3vjm

View 3vjm on RCSB PDB site
Description: Crystal structure of human depiptidyl peptidase IV (DPP-4) in complex with a prolylthiazolidine inhibitor #1
Class: hydrolase/hydrolase inhibitor
Keywords: ALPHA/BETA, BETA-PROPELLER, AMINOPEPTIDASE, SERINE PROTEASE, SIGNAL-ANCHOR, TRANSMEMBRANE, DIABETES, GLYCOPROTEIN, CELL MEMBRANE, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2011-10-24, released 2012-08-15
The last revision prior to the SCOPe 2.06 freeze date was dated 2012-08-15, with a file datestamp of 2012-08-10.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.187
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dipeptidyl peptidase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: DPP4, ADCP2, CD26
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3vjma1, d3vjma2
  • Chain 'B':
    Compound: dipeptidyl peptidase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: DPP4, ADCP2, CD26
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3vjmb1, d3vjmb2
  • Heterogens: W61, NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3vjmA (A:)
ddatadsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflen
stfdefghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnnt
qwvtwspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsays
alwwspngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvn
tdslssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdyde
ssgrwnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkk
dctfitkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpe
rcqyysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpsk
kldfiilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasten
iivasfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyg
gyvtsmvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsra
enfkqveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiy
thmshfikqcfslphhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3vjmA (A:)
dsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflenstfde
fghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvtw
spvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalwws
pngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdsls
svtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgrw
nclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctfi
tkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqyy
svsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldfi
ilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniivas
fdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvts
mvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfkq
veyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythmsh
fikqcfslp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3vjmB (B:)
ddatadsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflen
stfdefghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnnt
qwvtwspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsays
alwwspngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvn
tdslssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdyde
ssgrwnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkk
dctfitkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpe
rcqyysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpsk
kldfiilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasten
iivasfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyg
gyvtsmvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsra
enfkqveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiy
thmshfikqcfslphhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3vjmB (B:)
dsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflenstfde
fghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvtw
spvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalwws
pngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdsls
svtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgrw
nclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctfi
tkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqyy
svsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldfi
ilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniivas
fdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvts
mvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfkq
veyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythmsh
fikqcfslp