PDB entry 3vap
View 3vap on RCSB PDB site
Description: Synthesis and SAR Studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off target kinase selectivity
Class: transferase/transferase inhibitor
Keywords: kinase, cell cycle, inhibitor, transferase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on
2011-12-29, released
2012-05-02
The last revision prior to the SCOPe 2.03 freeze date was dated
2012-05-23, with a file datestamp of
2012-05-18.
Experiment type: XRAY
Resolution: 2.66 Å
R-factor: 0.205
AEROSPACI score: 0.29
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Aurora kinase A
Species: Homo sapiens [TaxId:9606]
Gene: AURKA, AIK, AIRK1, ARK1, AURA, AYK1, BTAK, IAK1, STK15, STK6
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.03: d3vapa_ - Heterogens: 0FY
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3vapA (A:)
gamgskrqwaledfeigrplgkgkfgnvylarekqskfilalkvlfkaqlekagvehqlr
reveiqshlrhpnilrlygyfhdatrvylileyaplgtvyrelqklskfdeqrtatyite
lanalsychskrvihrdikpenlllgsagelkiadfgwsvhapssrrttlcgtldylppe
miegrmhdekvdlwslgvlcyeflvgkppfeantyqetykrisrveftfpdfvtegardl
isrllkhnpsqrpmlrevlehpwitansskps
Sequence, based on observed residues (ATOM records): (download)
>3vapA (A:)
qwaledfeigrplgkgkfgnvylarekqskfilalkvlfkaqlekagvehqlrreveiqs
hlrhpnilrlygyfhdatrvylileyaplgtvyrelqklskfdeqrtatyitelanalsy
chskrvihrdikpenlllgsagelkiadfgwgtldylppemiegrmhdekvdlwslgvlc
yeflvgkppfeantyqetykrisrveftfpdfvtegardlisrllkhnpsqrpmlrevle
hpwitanss