PDB entry 3v8w

View 3v8w on RCSB PDB site
Description: Crystal Structure of Interleukin-2 Inducible T-cell Kinase Itk Catalytic Domain with Thienopyrazolylindole Inhibitor 469
Class: transferase/transferase inhibitor
Keywords: kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2011-12-23, released 2012-05-02
The last revision prior to the SCOPe 2.03 freeze date was dated 2012-05-02, with a file datestamp of 2012-04-27.
Experiment type: XRAY
Resolution: 2.27 Å
R-factor: 0.252
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase ITK/TSK
    Species: Homo sapiens [TaxId:9606]
    Gene: ITK, EMT, LYK
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q08881 (2-End)
      • expression tag (0-1)
    Domains in SCOPe 2.03: d3v8wa_
  • Chain 'B':
    Compound: Tyrosine-protein kinase ITK/TSK
    Species: Homo sapiens [TaxId:9606]
    Gene: ITK, EMT, LYK
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q08881 (2-End)
      • expression tag (0-1)
    Domains in SCOPe 2.03: d3v8wb_
  • Heterogens: 0G2, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3v8wA (A:)
gsvidpseltfvqeigsgqfglvhlgywlnkdkvaiktiregamseedfieeaevmmkls
hpklvqlygvcleqapiclvfefmehgclsdylrtqrglfaaetllgmcldvcegmayle
eacvihrdlaarnclvgenqvikvsdfgmtrfvlddqytsstgtkfpvkwaspevfsfsr
yssksdvwsfgvlmwevfsegkipyenrsnsevvedistgfrlykprlasthvyqimnhc
wkerpedrpafsrllrqlaeiaesgl

    Sequence, based on observed residues (ATOM records): (download) 
    >3v8wA (A:)
gsvidpseltfvqeigsgglvhlgywlnkdkvaiktirgamseedfieeaevmmklshpk
lvqlygvcleqapiclvfefmehgclsdylrtqrglfaaetllgmcldvcegmayleeac
vihrdlaarnclvgenqvikvsdfgpvkwaspevfsfsryssksdvwsfgvlmwevfseg
kipyersnsevvedistgfrlykprlasthvyqimnhcwkerpedrpafsrllrqlaeia
esg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3v8wB (B:)
gsvidpseltfvqeigsgqfglvhlgywlnkdkvaiktiregamseedfieeaevmmkls
hpklvqlygvcleqapiclvfefmehgclsdylrtqrglfaaetllgmcldvcegmayle
eacvihrdlaarnclvgenqvikvsdfgmtrfvlddqytsstgtkfpvkwaspevfsfsr
yssksdvwsfgvlmwevfsegkipyenrsnsevvedistgfrlykprlasthvyqimnhc
wkerpedrpafsrllrqlaeiaesgl

    Sequence, based on observed residues (ATOM records): (download) 
    >3v8wB (B:)
gsvidpseltfvqeigsgglvhlgywlnkdkvaiktirmseedfieeaevmmklshpklv
qlygvcleqapiclvfefmehgclsdylrtqrglfaaetllgmcldvcegmayleeacvi
hrdlaarnclvgenqvikvsdfgpvkwaspevfsfsryssksdvwsfgvlmwevfsegki
pyenrsnsevvedistgfrlykprlasthvyqimnhcwkerpedrpafsrllrqlaeiae
sg