PDB entry 3v5q

View 3v5q on RCSB PDB site
Description: Discovery of a selective TRK Inhibitor with efficacy in rodent cancer tumor models
Class: transferase/transferase inhibitor
Keywords: Kinase Domain, Kinase, Phosphorylation, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2011-12-16, released 2012-02-08
The last revision prior to the SCOPe 2.06 freeze date was dated 2012-02-08, with a file datestamp of 2012-02-03.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.214
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: NT-3 growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: NTRK3, TRKC
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16288 (8-296)
      • cloning artifact (5-7)
    Domains in SCOPe 2.06: d3v5qa1, d3v5qa2
  • Chain 'B':
    Compound: NT-3 growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: NTRK3, TRKC
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16288 (8-296)
      • cloning artifact (5-7)
    Domains in SCOPe 2.06: d3v5qb1, d3v5qb2
  • Heterogens: CL, 0F4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3v5qA (A:)
gamhsgihvqhikrrdivlkrelgegafgkvflaecynlsptkdkmlvavkalkdptlaa
rkdfqreaelltnlqhehivkfygvcgdgdplimvfeymkhgdlnkflrahgpdamilvd
gqprqakgelglsqmlhiasqiasgmvylasqhfvhrdlatrnclvganllvkigdfgms
rdvystdyyrvgghtmlpirwmppesimyrkfttesdvwsfgvilweiftygkqpwfqls
nteviecitqgrvlerprvcpkevydvmlgcwqrepqqrlnikeiykilhalgkatp

    Sequence, based on observed residues (ATOM records): (download) 
    >3v5qA (A:)
gihvqhikrrdivlkrelkvflaecynlsptkdkmlvavkalptlaarkdfqreaelltn
lqhehivkfygvcgdgdplimvfeymkhgdlnkflrahgpelglsqmlhiasqiasgmvy
lasqhfvhrdlatrnclvganllvkigdfgmdvystdyyrtmlpirwmppesimyrkftt
esdvwsfgvilweiftygkqpwfqlsnteviecitqgrvlerprvcpkevydvmlgcwqr
epqqrlnikeiykilhalgkatp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3v5qB (B:)
gamhsgihvqhikrrdivlkrelgegafgkvflaecynlsptkdkmlvavkalkdptlaa
rkdfqreaelltnlqhehivkfygvcgdgdplimvfeymkhgdlnkflrahgpdamilvd
gqprqakgelglsqmlhiasqiasgmvylasqhfvhrdlatrnclvganllvkigdfgms
rdvystdyyrvgghtmlpirwmppesimyrkfttesdvwsfgvilweiftygkqpwfqls
nteviecitqgrvlerprvcpkevydvmlgcwqrepqqrlnikeiykilhalgkatp

    Sequence, based on observed residues (ATOM records): (download) 
    >3v5qB (B:)
gihvqhikrrdivlkrelgfkvflaecynlsptkdkmlvavkalkdptlaarkdfqreae
lltnlqhehivkfygvcgdplimvfeymkhgdlnkflrahgpelglsqmlhiasqiasgm
vylasqhfvhrdlatrnclvganllvkigdfgmdvystdyyrtmlpirwmppesimyrkf
ttesdvwsfgvilweiftygkqpwfqlsnteviecitqgrvlerprvcpkevydvmlgcw
qrepqqrlnikeiykilhalgkatp