PDB entry 3uvx

View 3uvx on RCSB PDB site
Description: Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated histone 4 peptide (H4K12acK16ac)
Class: transcription/protein binding
Keywords: Bromodomain, Bromodomain containing protein 4, CAP, HUNK1, MCAP, Mitotic chromosome associated protein, peptide complex, Structural Genomics Consortium, SGC, TRANSCRIPTION-PROTEIN BINDING complex
Deposited on 2011-11-30, released 2012-01-25
The last revision prior to the SCOPe 2.07 freeze date was dated 2012-08-29, with a file datestamp of 2012-08-24.
Experiment type: XRAY
Resolution: 1.91 Å
R-factor: 0.17
AEROSPACI score: 0.51 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Bromodomain-containing protein 4
  Species: Homo sapiens [TaxId:9606]
  Gene: BRD4, HUNK1
  Database cross-references and differences (RAF-indexed):
  • Uniprot O60885 (2-126)
    • expression tag (0-1)
  Domains in SCOPe 2.07: d3uvxa1, d3uvxa2
• Chain 'B':
  Compound: diacetylated histone 4 peptide
  Species: synthetic, synthetic
  Database cross-references and differences (RAF-indexed):
  • PDB 3UVX (0-End)
• Heterogens: NA, EDO, FMT, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3uvxA (A:)
  smnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
  ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
  nelptee
  

  
  
• Chain 'B':
  No sequence available.