PDB entry 3uq1
View 3uq1 on RCSB PDB site
Description: Crystal structure of the pre-catalytic ternary complex of polymerase lambda with a dATP analog opposite a templating T and a rCMP at the primer terminus.
Class: transferase, lyase/DNA
Keywords: DNA polymerase lambda, ribonucleotide incorporation, Protein Conformation, TRANSFERASE, LYASE-DNA complex
Deposited on
2011-11-18, released
2012-05-23
The last revision prior to the SCOPe 2.08 freeze date was dated
2012-07-11, with a file datestamp of
2012-07-06.
Experiment type: XRAY
Resolution: 2.01 Å
R-factor: 0.19
AEROSPACI score: 0.46
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: DNA polymerase lambda
Species: Homo sapiens [TaxId:9606]
Gene: POLL
Database cross-references and differences (RAF-indexed):
- Uniprot Q9UGP5 (Start-328)
- see remark 999 (221-224)
- engineered mutation (296)
Domains in SCOPe 2.08: d3uq1a1, d3uq1a2, d3uq1a3 - Chain 'D':
Compound: 5'-d(p*gp*cp*cp*g)-3'
- Chain 'H':
Compound: 5'-d(p*tp*ap*cp*tp*g)-3'
- Chain 'I':
Compound: 5'-d(p*cp*ap*gp*tp*a)-3'
- Chain 'P':
Compound: 5'-d(*cp*ap*gp*tp*ap)-r(p*c)-3'
- Chain 'T':
Compound: 5'-d(*cp*gp*gp*cp*tp*gp*tp*ap*cp*tp*g)-3'
- Heterogens: MG, NA, CL, MN, F2A, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3uq1A (A:)
aqpssqkatnhnlhiteklevlakaysvqgdkwralgyakainalksfhkpvtsyqeacs
ipgigkrmaekiieilesghlrkldhisesvpvlelfsniwgagtktaqmwyqqgfrsle
dirsqaslttqqaiglkhysdflermpreeateieqtvqkaaqafnsgllcvacgsyrrg
katcgdvdvlithpdgrshrgifsrlldslrqegfltddlvkgetkylgvcrlpgpgrrh
rrldiivvpysefacallyftgsahfnrsmralaktkgmslsehalstavvrnthgakvg
pgrvlptptekdvfrllglpyrepaerdw
Sequence, based on observed residues (ATOM records): (download)
>3uq1A (A:)
hnlhiteklevlakaysvqgdkwralgyakainalksfhkpvtsyqeacsipgigkrmae
kiieilesghlrkldhisesvpvlelfsniwgagtktaqmwyqqgfrsledirsqasltt
qqaiglkhysdflermpreeateieqtvqkaaqafnsgllcvacgsyrrgkatcgdvdvl
ithpdggifsrlldslrqegfltddlvkgetkylgvcrlpgpgrrhrrldiivvpysefa
callyftgsahfnrsmralaktkgmslsehalstavvrnthgakvgpgrvlptptekdvf
rllglpyrepaerdw
- Chain 'D':
No sequence available.
- Chain 'H':
No sequence available.
- Chain 'I':
No sequence available.
- Chain 'P':
No sequence available.
- Chain 'T':
No sequence available.