PDB entry 3ug2

View 3ug2 on RCSB PDB site
Description: Crystal structure of the mutated EGFR kinase domain (G719S/T790M) in complex with gefitinib
Class: transferase/transferase inhibitor
Keywords: kinase, tyrosine-protein kinase, ATP binding, phosphorylation, transmembrane, receptor, disease mutation, cell cycle, drug resistance, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2011-11-02, released 2012-03-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-10-15, with a file datestamp of 2014-10-10.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.186
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • engineered mutation (30)
      • engineered mutation (101)
    Domains in SCOPe 2.08: d3ug2a_
  • Heterogens: IRE, MES, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3ug2A (A:)
gamgirsgeapnqallrilketefkkikvlssgafgtvykglwipegekvkipvaikelr
eatspkankeildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdn
igsqyllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeeke
yhaeggkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissile
kgerlpqppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermh
lpsptdsnfyralmdeedmddvvdadeylipqqg

    Sequence, based on observed residues (ATOM records): (download) 
    >3ug2A (A:)
eapnqallrilketefkkikvlssgtvykglwipegekvkipvaikespkankeildeay
vmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcvqiakg
mnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggkvpikwmale
silhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvy
mimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhledmddvvdadeyli