PDB entry 3ucb

View 3ucb on RCSB PDB site
Description: Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 in Complex with Darunavir
Class: Hydrolase/Hydrolase inhibitor
Keywords: Hydrolase-Hydrolase inhibitor complex
Deposited on 2011-10-26, released 2012-03-28
The last revision prior to the SCOPe 2.06 freeze date was dated 2012-10-17, with a file datestamp of 2012-10-12.
Experiment type: XRAY
Resolution: 1.38 Å
R-factor: 0.165
AEROSPACI score: 0.69 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Protease
  Species: HUMAN IMMUNODEFICIENCY VIRUS 1 [TaxId:11676]
  Gene: pol
  Database cross-references and differences (RAF-indexed):
  • Uniprot P03367 (0-98)
    • engineered mutation (6)
    • engineered mutation (9)
    • engineered mutation (12)
    • engineered mutation (14)
    • engineered mutation (29)
    • engineered mutation (31-32)
    • engineered mutation (34-36)
    • engineered mutation (46)
    • engineered mutation (53)
    • engineered mutation (57)
    • engineered mutation (61-62)
    • engineered mutation (66)
    • engineered mutation (70)
    • engineered mutation (83)
    • engineered mutation (87-89)
    • engineered mutation (94)
  Domains in SCOPe 2.06: d3ucba_
• Chain 'B':
  Compound: Protease
  Species: HUMAN IMMUNODEFICIENCY VIRUS 1 [TaxId:11676]
  Gene: pol
  Database cross-references and differences (RAF-indexed):
  • Uniprot P03367 (0-98)
    • engineered mutation (6)
    • engineered mutation (9)
    • engineered mutation (12)
    • engineered mutation (14)
    • engineered mutation (29)
    • engineered mutation (31-32)
    • engineered mutation (34-36)
    • engineered mutation (46)
    • engineered mutation (53)
    • engineered mutation (57)
    • engineered mutation (61-62)
    • engineered mutation (66)
    • engineered mutation (70)
    • engineered mutation (83)
    • engineered mutation (87-89)
    • engineered mutation (94)
  Domains in SCOPe 2.06: d3ucbb_
• Heterogens: 017, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3ucbA (A:)
  pqitlwkrpfvtvkvggqlkealldtgadntifedinlpgrwkpkmvggiggflkvreyd
  qvpieiaghkvigtvlvgptpvnvigrdtmtqigatlnf
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3ucbB (B:)
  pqitlwkrpfvtvkvggqlkealldtgadntifedinlpgrwkpkmvggiggflkvreyd
  qvpieiaghkvigtvlvgptpvnvigrdtmtqigatlnf