PDB entry 3u88

View 3u88 on RCSB PDB site
Description: Crystal structure of human menin in complex with MLL1 and LEDGF
Class: transcription
Keywords: menin, MEN1, MLL, JunD, LEDGF, TPR, TRANSCRIPTION
Deposited on 2011-10-16, released 2012-02-15
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-06-21, with a file datestamp of 2017-06-16.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Menin
    Species: Homo sapiens [TaxId:9606]
    Gene: MEN1, SCG2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3u88a1, d3u88a2
  • Chain 'B':
    Compound: Menin
    Species: Homo sapiens [TaxId:9606]
    Gene: MEN1, SCG2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3u88b1, d3u88b2
  • Chain 'C':
    Compound: Lens epithelium-derived growth factor
    Species: Homo sapiens [TaxId:9606]
    Gene: PSIP1, DFS70, LEDGF, PSIP2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3u88c_
  • Chain 'D':
    Compound: Lens epithelium-derived growth factor
    Species: Homo sapiens [TaxId:9606]
    Gene: PSIP1, DFS70, LEDGF, PSIP2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3u88d_
  • Chain 'M':
    Compound: Histone-lysine N-methyltransferase 2A
    Species: Homo sapiens [TaxId:9606]
    Gene: KMT2A, ALL1, CXXC7, HRX, HTRX, MLL, MLL1, TRX1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q03164 (24-End)
      • expression tag (1-23)
  • Chain 'N':
    Compound: Histone-lysine N-methyltransferase 2A
    Species: Homo sapiens [TaxId:9606]
    Gene: KMT2A, ALL1, CXXC7, HRX, HTRX, MLL, MLL1, TRX1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q03164 (24-End)
      • expression tag (1-23)
  • Heterogens: CHD, GGB, 0BR, GLV, SO4

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3u88A (A:)
    sglkaaqktlfplrsiddvvrlfaaelgreepdlvllslvlgfvehflavnrviptnvpe
    ltfqpspapdppggltyfpvadlsiiaalyarftaqirgavdlslypreggvssrelvkk
    vsdviwnslsrsyfkdrahiqslfsfitgtkldssgvafavvgacqalglrdvhlalsed
    hawvvfgpngeqtaevtwhgkgnedrrgqtvnagvaerswlylkgsymrcdrkmevafmv
    cainpsidlhtdslellqlqqkllwllydlghlerypmalgnladleeleptpgrpdplt
    lyhkgiasaktyyrdehiypymylagyhcrnrnvrealqawadtatviqdynycredeei
    ykeffevandvipnllkeaaslleageerpgeqsqgtqsqgsalqdpecfahllrfydgi
    ckweegsptpvlhvgwatflvqslgrfegqvrqkvrivsgtvagtargpeggstaqvpap
    taspppegpvltfqsekmkgmkellvatkinssaiklqltaqsqvqmkkqkvstpsdytl
    sflkrqrkgl
    

    Sequence, based on observed residues (ATOM records): (download)
    >3u88A (A:)
    glkaaqktlfplrsiddvvrlfaaelgreepdlvllslvlgfvehflavnrviptnvpel
    tfqpspapdggltyfpvadlsiiaalyarftaqirgavdlslypreggvssrelvkkvsd
    viwnslsrsyfkdrahiqslfsfitgtkldssgvafavvgacqalglrdvhlalsedhaw
    vvfgpngeqtaevtwhgkgnedrrgqtvnagvaerswlylkgsymrcdrkmevafmvcai
    npsidlhtdslellqlqqkllwllydlghlerypmalgnladleeleptpgrpdpltlyh
    kgiasaktyyrdehiypymylagyhcrnrnvrealqawadtatviqdynycredeeiyke
    ffevandvipnllkeaaslleasalqdpecfahllrfydgickweegsptpvlhvgwatf
    lvqslgrfegqvrqkvrivsegpvltfqsekmkgmkellvatkinssaiklqltaqs
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3u88B (B:)
    sglkaaqktlfplrsiddvvrlfaaelgreepdlvllslvlgfvehflavnrviptnvpe
    ltfqpspapdppggltyfpvadlsiiaalyarftaqirgavdlslypreggvssrelvkk
    vsdviwnslsrsyfkdrahiqslfsfitgtkldssgvafavvgacqalglrdvhlalsed
    hawvvfgpngeqtaevtwhgkgnedrrgqtvnagvaerswlylkgsymrcdrkmevafmv
    cainpsidlhtdslellqlqqkllwllydlghlerypmalgnladleeleptpgrpdplt
    lyhkgiasaktyyrdehiypymylagyhcrnrnvrealqawadtatviqdynycredeei
    ykeffevandvipnllkeaaslleageerpgeqsqgtqsqgsalqdpecfahllrfydgi
    ckweegsptpvlhvgwatflvqslgrfegqvrqkvrivsgtvagtargpeggstaqvpap
    taspppegpvltfqsekmkgmkellvatkinssaiklqltaqsqvqmkkqkvstpsdytl
    sflkrqrkgl
    

    Sequence, based on observed residues (ATOM records): (download)
    >3u88B (B:)
    glkaaqktlfplrsiddvvrlfaaelgreepdlvllslvlgfvehflavnrviptnvpel
    tfqpspapdppggltyfpvadlsiiaalyarftaqirgavdlslypreggvssrelvkkv
    sdviwnslsrsyfkdrahiqslfsfitgtkldssgvafavvgacqalglrdvhlalsedh
    awvvfgpngeqtaevtwhgkgnedrrgqtvnagvaerswlylkgsymrcdrkmevafmvc
    ainpsidlhtdslellqlqqkllwllydlghlerypmalgnladleeleptpgrpdpltl
    yhkgiasaktyyrdehiypymylagyhcrnrnvrealqawadtatviqdynycredeeiy
    keffevandvipnllkeaaslleagqgsalqdpecfahllrfydgickweegsptpvlhv
    gwatflvqslgrfegqvrqkvrivsgpppegpvltfqsekmkgmkellvatkinssaikl
    qltaq
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >3u88C (C:)
    smdsrlqrihaeiknslkidnldvnrciealdelaslqvtmqqaqkhtemittlkkirrf
    kvsqvimekstmlynkfknmflvgegdsv
    

    Sequence, based on observed residues (ATOM records): (download)
    >3u88C (C:)
    mdsrlqrihaeiknslkidnldvnrciealdelaslqvtmqqaqkhtemittlkkirrfk
    vsqvimekstmlynkfknmflv
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >3u88D (D:)
    smdsrlqrihaeiknslkidnldvnrciealdelaslqvtmqqaqkhtemittlkkirrf
    kvsqvimekstmlynkfknmflvgegdsv
    

    Sequence, based on observed residues (ATOM records): (download)
    >3u88D (D:)
    qrihaeiknslvnrciealdelaslqvtmqqaqkhtemittlkkirqvimekstmlynkf
    knmflvg
    

  • Chain 'M':
    No sequence available.

  • Chain 'N':
    No sequence available.