PDB entry 3tkd
View 3tkd on RCSB PDB site
Description: Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and cyclothiazide at 1.45 A resolution
Class: membrane protein
Keywords: ampa receptor ligand-binding domain, glua2 s1s2j-l483y-n754s, cyclothiazide, allosteric modulation, membrane protein
Deposited on
2011-08-26, released
2011-09-21
The last revision prior to the SCOPe 2.08 freeze date was dated
2017-08-09, with a file datestamp of
2017-08-04.
Experiment type: XRAY
Resolution: 1.45 Å
R-factor: N/A
AEROSPACI score: 0.51
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Glutamate receptor 2
Species: Rattus norvegicus [TaxId:10116]
Gene: Gria2, Glur2
Database cross-references and differences (RAF-indexed):
- Uniprot P19491 (2-116)
- expression tag (0-1)
- engineered mutation (93)
- linker (117-118)
- Uniprot P19491 (119-261)
- engineered mutation (241)
Domains in SCOPe 2.08: d3tkda1, d3tkda2 - Chain 'B':
Compound: Glutamate receptor 2
Species: Rattus norvegicus [TaxId:10116]
Gene: Gria2, Glur2
Database cross-references and differences (RAF-indexed):
- Uniprot P19491 (Start-116)
- engineered mutation (93)
- linker (117-118)
- Uniprot P19491 (119-261)
- engineered mutation (241)
Domains in SCOPe 2.08: d3tkdb_ - Heterogens: GLU, CYZ, SO4, GOL, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3tkdA (A:)
ganktvvvttilespyvmmkknhemlegneryegycvdlaaeiakhcgfkykltivgdgk
ygardadtkiwngmvgelvygkadiaiapltityvreevidfskpfmslgisimikkgtp
iesaedlskqteiaygtldsgstkeffrrskiavfdkmwtymrsaepsvfvrttaegvar
vrkskgkyayllestmneyieqrkpcdtmkvggnldskgygiatpkgsslgnavnlavlk
lseqglldklknkwwydkgecgs
Sequence, based on observed residues (ATOM records): (download)
>3tkdA (A:)
ganktvvvttilespyvmmkknhemlegneryegycvdlaaeiakhcgfkykltivgdgk
ygardadtkiwngmvgelvygkadiaiapltityvreevidfskpfmslgisimikkgtp
iesaedlskqteiaygtldsgstkeffrrskiavfdkmwtymrsaepsvfvrttaegvar
vrkskgkyayllestmneyieqrkpcdtmkvggnldskgygiatpkgsslgnavnlavlk
lseqglldklknkwwydkgecg
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3tkdB (B:)
ganktvvvttilespyvmmkknhemlegneryegycvdlaaeiakhcgfkykltivgdgk
ygardadtkiwngmvgelvygkadiaiapltityvreevidfskpfmslgisimikkgtp
iesaedlskqteiaygtldsgstkeffrrskiavfdkmwtymrsaepsvfvrttaegvar
vrkskgkyayllestmneyieqrkpcdtmkvggnldskgygiatpkgsslgnavnlavlk
lseqglldklknkwwydkgecgs
Sequence, based on observed residues (ATOM records): (download)
>3tkdB (B:)
ktvvvttilespyvmmkknhemlegneryegycvdlaaeiakhcgfkykltivgdgkyga
rdadtkiwngmvgelvygkadiaiapltityvreevidfskpfmslgisimikkgtpies
aedlskqteiaygtldsgstkeffrrskiavfdkmwtymrsaepsvfvrttaegvarvrk
skgkyayllestmneyieqrkpcdtmkvggnldskgygiatpkgsslgnavnlavlklse
qglldklknkwwydkgecgs