PDB entry 3tgx

View 3tgx on RCSB PDB site
Description: IL-21:IL21R complex
Class: cytokine/cytokine receptor
Keywords: Class I cytokine, Class I cytokine Receptor, sugarbridge, Fibronectin domain, Signaling, CYTOKINE-CYTOKINE RECEPTOR complex
Deposited on 2011-08-18, released 2012-02-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Interleukin-21 receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: IL21R, NILR, UNQ3121/PRO10273
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9HBE5 (0-End)
      • engineered mutation (77)
      • engineered mutation (84)
      • engineered mutation (105)
      • engineered mutation (115)
  • Chain 'B':
    Compound: Interleukin-21
    Species: Homo sapiens [TaxId:9606]
    Gene: IL21
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3tgxb_
  • Chain 'C':
    Compound: Interleukin-21 receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: IL21R, NILR, UNQ3121/PRO10273
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9HBE5 (0-End)
      • engineered mutation (77)
      • engineered mutation (84)
      • engineered mutation (105)
      • engineered mutation (115)
  • Chain 'D':
    Compound: Interleukin-21
    Species: Homo sapiens [TaxId:9606]
    Gene: IL21
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3tgxd_
  • Chain 'E':
    Compound: Interleukin-21 receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: IL21R, NILR, UNQ3121/PRO10273
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9HBE5 (0-End)
      • engineered mutation (77)
      • engineered mutation (84)
      • engineered mutation (105)
      • engineered mutation (115)
  • Chain 'F':
    Compound: Interleukin-21
    Species: Homo sapiens [TaxId:9606]
    Gene: IL21
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3tgxf_
  • Chain 'G':
    Compound: Interleukin-21 receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: IL21R, NILR, UNQ3121/PRO10273
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9HBE5 (0-End)
      • engineered mutation (77)
      • engineered mutation (84)
      • engineered mutation (105)
      • engineered mutation (115)
  • Chain 'H':
    Compound: Interleukin-21
    Species: Homo sapiens [TaxId:9606]
    Gene: IL21
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3tgxh_
  • Chain 'I':
    Compound: Interleukin-21 receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: IL21R, NILR, UNQ3121/PRO10273
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9HBE5 (0-End)
      • engineered mutation (77)
      • engineered mutation (84)
      • engineered mutation (105)
      • engineered mutation (115)
  • Chain 'J':
    Compound: Interleukin-21
    Species: Homo sapiens [TaxId:9606]
    Gene: IL21
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3tgxj_
  • Chain 'K':
    Compound: Interleukin-21 receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: IL21R, NILR, UNQ3121/PRO10273
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9HBE5 (0-End)
      • engineered mutation (77)
      • engineered mutation (84)
      • engineered mutation (105)
      • engineered mutation (115)
  • Chain 'L':
    Compound: Interleukin-21
    Species: Homo sapiens [TaxId:9606]
    Gene: IL21
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3tgxl_
  • Chain 'M':
    Compound: Interleukin-21 receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: IL21R, NILR, UNQ3121/PRO10273
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9HBE5 (0-End)
      • engineered mutation (77)
      • engineered mutation (84)
      • engineered mutation (105)
      • engineered mutation (115)
  • Chain 'N':
    Compound: Interleukin-21
    Species: Homo sapiens [TaxId:9606]
    Gene: IL21
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3tgxn_
  • Chain 'O':
    Compound: Interleukin-21 receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: IL21R, NILR, UNQ3121/PRO10273
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9HBE5 (0-End)
      • engineered mutation (77)
      • engineered mutation (84)
      • engineered mutation (105)
      • engineered mutation (115)
  • Chain 'P':
    Compound: Interleukin-21
    Species: Homo sapiens [TaxId:9606]
    Gene: IL21
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3tgxp_
  • Heterogens: MAN, NI, SO4

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3tgxB (B:)
mqgqdrhmirmrqlidivdqlknyvndlvpeflpapedvetncewsafscfqkaqlksan
tgnneriinvsikklkrkppstnagrrqkhrltcpscdsyekkppkeflerfksllqkmi
hqhlssrthgseds

    Sequence, based on observed residues (ATOM records): (download) 
    >3tgxB (B:)
gqdrhmirmrqlidivdqlknyvndlvpeflpapedvetncewsafscfqkaqlksantg
nneriinvsikklkrkppsthrltcpscdsyekkppkeflerfksllqkmihqhl

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3tgxD (D:)
mqgqdrhmirmrqlidivdqlknyvndlvpeflpapedvetncewsafscfqkaqlksan
tgnneriinvsikklkrkppstnagrrqkhrltcpscdsyekkppkeflerfksllqkmi
hqhlssrthgseds

    Sequence, based on observed residues (ATOM records): (download) 
    >3tgxD (D:)
gqdrhmirmrqlidivdqlknyvndlvpeflpapedvetncewsafscfqkaqlksantg
nneriinvsikklkrkppstnagrltcpscdsyekkppkeflerfksllqkmihqhl

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >3tgxF (F:)
mqgqdrhmirmrqlidivdqlknyvndlvpeflpapedvetncewsafscfqkaqlksan
tgnneriinvsikklkrkppstnagrrqkhrltcpscdsyekkppkeflerfksllqkmi
hqhlssrthgseds

    Sequence, based on observed residues (ATOM records): (download) 
    >3tgxF (F:)
gqdrhmirmrqlidivdqlknyvndlvpeflpapedvetncewsafscfqkaqlksantg
nneriinvsikklkrkppstntcpscdsyekkppkeflerfksllqkmihqhl

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >3tgxH (H:)
mqgqdrhmirmrqlidivdqlknyvndlvpeflpapedvetncewsafscfqkaqlksan
tgnneriinvsikklkrkppstnagrrqkhrltcpscdsyekkppkeflerfksllqkmi
hqhlssrthgseds

    Sequence, based on observed residues (ATOM records): (download) 
    >3tgxH (H:)
drhmirmrqlidivdqlknyvndlvpeflpapedvetncewsafscfqkaqlksantgnn
eriinvsikklkrkppstnqkhrltcpscdsyekkppkeflerfksllqkmihqhl

  • Chain 'I':
    No sequence available.

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >3tgxJ (J:)
mqgqdrhmirmrqlidivdqlknyvndlvpeflpapedvetncewsafscfqkaqlksan
tgnneriinvsikklkrkppstnagrrqkhrltcpscdsyekkppkeflerfksllqkmi
hqhlssrthgseds

    Sequence, based on observed residues (ATOM records): (download) 
    >3tgxJ (J:)
gqdrhmirmrqlidivdqlknyvndlvpeflpapedvetncewsafscfqkaqlksantg
nneriinvsikklkrkppstltcpscdsyekkppkeflerfksllqkmihqhlssr

  • Chain 'K':
    No sequence available.

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >3tgxL (L:)
mqgqdrhmirmrqlidivdqlknyvndlvpeflpapedvetncewsafscfqkaqlksan
tgnneriinvsikklkrkppstnagrrqkhrltcpscdsyekkppkeflerfksllqkmi
hqhlssrthgseds

    Sequence, based on observed residues (ATOM records): (download) 
    >3tgxL (L:)
drhmirmrqlidivdqlknyvndlvpeflpapedvetncewsafscfqkaqlksantgnn
eriinvsikklkrkppstltcpscdsyekkppkeflerfksllqkmihqh

  • Chain 'M':
    No sequence available.

  • Chain 'N':
    Sequence, based on SEQRES records: (download) 
    >3tgxN (N:)
mqgqdrhmirmrqlidivdqlknyvndlvpeflpapedvetncewsafscfqkaqlksan
tgnneriinvsikklkrkppstnagrrqkhrltcpscdsyekkppkeflerfksllqkmi
hqhlssrthgseds

    Sequence, based on observed residues (ATOM records): (download) 
    >3tgxN (N:)
drhmirmrqlidivdqlknyvndlvpeflpapedvetncewsafscfqkaqlksantgnn
eriinvsikklkrkppsttcpscdsyekkppkeflerfksllqkmih

  • Chain 'O':
    No sequence available.

  • Chain 'P':
    Sequence, based on SEQRES records: (download) 
    >3tgxP (P:)
mqgqdrhmirmrqlidivdqlknyvndlvpeflpapedvetncewsafscfqkaqlksan
tgnneriinvsikklkrkppstnagrrqkhrltcpscdsyekkppkeflerfksllqkmi
hqhlssrthgseds

    Sequence, based on observed residues (ATOM records): (download) 
    >3tgxP (P:)
drhmirmrqlidivdqlknyvndlvpeflpapedvetncewsafscfqkaqlksantgnn
eriinvsikklkrkppsttcpscdsyekkppkeflerfksllqkmihqhl